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Twisted nanoribbons...
Twisted nanoribbons from a RGD-bearing cholic acid derivative
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- Travaglini, Leana (författare)
- Sapienza University of Rome
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- Giordano, Cesare (författare)
- CNR Istituto per le Tecnologie Applicate ai Beni Culturali (CNR-ITABC)
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- D'Annibale, Andrea (författare)
- Sapienza University of Rome
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- Gubitosi, Marta (författare)
- Sapienza University of Rome
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- di Gregorio, Maria Chiara (författare)
- Sapienza University of Rome
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- Schillén, Karin (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Stefanucci, Azzurra (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Mollica, Adriano (författare)
- University G.d'Annunzio of Chieti-Pescara
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- Pavel, Nicolae Viorel (författare)
- Sapienza University of Rome
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- Galantini, Luciano (författare)
- Sapienza University of Rome
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska 8 s.
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Ingår i: Colloids and Surfaces B: Biointerfaces. - : Elsevier BV. - 0927-7765. ; 159, s. 183-190
- Relaterad länk:
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http://dx.doi.org/10...
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https://iris.uniroma...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In light of the biomedical interest for self-assembling amphiphiles bearing the tripeptide Arg-Gly-Gly (RGD), a cholic acid derivative was synthesized by introducing an aromatic moiety on the steroidal skeleton and the RGD sequence on the carboxylic function of its chain 17–24, thus forming a peptide amphiphile with the unconventional rigid amphiphilic structure of bile salts. In aqueous solution, the compound self-assembled into long twisted ribbons characterized by a very low degree of polydispersity in terms of width (≈25 nm), thickness (≈4.5 nm) and pitch (≈145 nm). It was proposed that in the ribbon the molecules are arranged in a bilayer structure with the aromatic moieties in the interior, strongly involved in the intermolecular interaction, whereas the RGD residues are located at the bilayer-water interface. The nanostructure is significantly different from those generally provided by RGD-containing amphiphiles with the conventional peptide-tail structure, for which fibers with a circular cross-section were observed, and successfully tested as scaffolds for tissue regeneration. From previous work on the use of this kind of nanostructures, it is known that features like morphology, rigidity, epitope spacing and periodicity are important factors that dramatically affect cell adhesion and signaling. Within this context, the reported results demonstrate that bile salt-based peptide surfactants are promising building blocks in the preparation of non-trivial RGD-decorated nanoaggregates with well-defined morphologies and epitope distributions.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Bile acids
- RGD amphiphiles
- Self-assembly
- Supramolecular nanoribbons
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Travaglini, Lean ...
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Giordano, Cesare
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D'Annibale, Andr ...
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Gubitosi, Marta
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di Gregorio, Mar ...
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Schillén, Karin
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visa fler...
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Stefanucci, Azzu ...
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Mollica, Adriano
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Pavel, Nicolae V ...
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Galantini, Lucia ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
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Colloids and Sur ...
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Lunds universitet