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  • Thörnerup, IngridLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine (author)

Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry.

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-01-20
  • Wiley,2011

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4ace96e1-6de7-45b8-87b3-1cbc2caf7293
  • https://lup.lub.lu.se/record/1777237URI
  • https://doi.org/10.1111/j.1365-2141.2010.08456.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-82259URI
  • https://gup.ub.gu.se/publication/143090URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147836URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:121990475URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66314URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Minimal residual disease (MRD) assessment is a powerful prognostic factor for determining the risk of relapse in childhood acute lymphoblastic leukaemia (ALL). In this Swedish multi-centre study of childhood ALL diagnosed between 2002 and 2006, the MRD levels were analysed in 726 follow-up samples in 228 children using real-time quantitative polymerase chain reaction (RQ-PCR) of rearranged immunoglobulin/T-cell receptor genes and multicolour flow cytometry (FCM). Using an MRD threshold of 0·1%, which was the sensitivity level reached in all analyses, the concordance between RQ-PCR and FCM MRD values at day 29 was 84%. In B-cell precursor ALL, an MRD level of ≥0·1% at day 29 predicted a higher risk of bone marrow relapse (BMR) with both methods, although FCM was a better discriminator. However, considering the higher median MRD values achieved with RQ-PCR, a higher MRD cut-off (≥0·2%) improved the predictive capacity of RQ-PCR. In T-ALL, RQ-PCR was notably superior to FCM in predicting risk of BMR. That notwithstanding, MRD levels of ≥0·1%, detected by either method at day 29, could not predict isolated extramedullary relapse. In conclusion, the concordance between RQ-PCR and FCM was high and hence both methods are valuable clinical tools for identifying childhood ALL cases with increased risk of BMR.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Forestier, ErikUmeå universitet,Medicinsk och klinisk genetik,Pediatrik,Department of Clinical Sciences, Paediatrics, Umeå University, Umeå(Swepub:umu)erfo0007 (author)
  • Botling, JohanUppsala universitet,Molekylär och morfologisk patologi,Forskargrupp Botling,Uppsala University(Swepub:uu)johanbot (author)
  • Thuresson, BrittLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)tran-bth (author)
  • Wasslavik, CarinaSahlgrens University Hospital(Swepub:gu)xwacar (author)
  • Björklund, ElisabetKarolinska University Hospital (author)
  • Li, AihongUmeå universitet,Klinisk kemi,Umea University(Swepub:umu)liai0001 (author)
  • Lindström-Eriksson, EleonorUmea University (author)
  • Malec, MariaKarolinska University Hospital (author)
  • Grönlund, ElisabethUmeå universitet,Patologi,Umea University(Swepub:umu)elgr0033 (author)
  • Torikka, KerstinLund University (author)
  • Heldrup, JesperLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University Lund Hospital(Swepub:lu)med-jrh (author)
  • Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens University Hospital(Swepub:gu)xabrjo (author)
  • Behrendtz, MikaelLinköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping,Pediatrik,Hälsouniversitetet (author)
  • Söderhäll, StefanKarolinska Institutet,Sahlgrens University Hospital (author)
  • Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine(Swepub:gu)xjacst (author)
  • Olofsson, TorLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)efor-tol (author)
  • Porwit, AnnaKarolinska Institutet,Karolinska University Hospital (author)
  • Lönnerholm, GudmarUppsala universitet,Pediatrik,Barnonkologisk forskning/Pfeifer,Uppsala University(Swepub:uu)gudmarlh (author)
  • Rosenquist, RichardUppsala universitet,Hematologi och immunologi,Forskargrupp Rosenquist Brandell,Uppsala University(Swepub:uu)richrose (author)
  • Sundström, ChristerUppsala universitet,Molekylär och morfologisk patologi,Forskargrupp Alafuzoff,Uppsala University(Swepub:uu)chrisund (author)
  • Thörn, IngridUppsala universitet,Molekylär och morfologisk patologi,Forskargrupp Alafuzoff,Uppsala University(Swepub:uu)intho172 (author)
  • Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten (creator_code:org_t)

Related titles

  • In:British Journal of Haematology: Wiley152:6, s. 743-7530007-10481365-2141

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