Search: WFRF:(Edwards Todd L) >
Relationship betwee...
Relationship between Blood Pressure and Incident Cardiovascular Disease : Linear and Nonlinear Mendelian Randomization Analyses
-
- Malik, Rainer (author)
- University Hospital Munich
-
- Georgakis, Marios K. (author)
- University Hospital Munich
-
- Vujkovic, Marijana (author)
- Cochin Hospital,Veterans Health Administration
-
show more...
-
- Damrauer, Scott M. (author)
- Cochin Hospital,Veterans Health Administration
-
- Elliott, Paul (author)
- MRC Human Nutrition Research,Imperial College Healthcare NHS Trust,Health Data Research UK,British Heart Foundation,Imperial College London
-
- Karhunen, Ville (author)
- Imperial College London
-
- Giontella, Alice (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Verona
-
- Fava, Cristiano (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,University of Verona
-
- Hellwege, Jacklyn N. (author)
- Vanderbilt University
-
- Shuey, Megan M. (author)
- Vanderbilt University
-
- Edwards, Todd L. (author)
- Vanderbilt University
-
- Rogne, Tormod (author)
- Norwegian University of Science and Technology,Yale University,St. Olav’s University Hospital
-
- Åsvold, Bjørn O. (author)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
-
- Brumpton, Ben M. (author)
- St. Olav’s University Hospital
-
- Burgess, Stephen (author)
- University of Cambridge
-
- Dichgans, Martin (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Munich
-
- Gill, Dipender (author)
- Imperial College London,British Heart Foundation,St George's Hospital, London,St George's, University of London,Novo Nordisk Research Centre Oxford
-
show less...
-
(creator_code:org_t)
- 2021
- 2021
- English 10 s.
-
In: Hypertension. - 0194-911X. ; 77:6, s. 2004-2013
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Observational studies exploring whether there is a nonlinear effect of blood pressure on cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be overcome by leveraging randomly allocated genetic variants in nonlinear Mendelian randomization analyses. Based on their association with blood pressure traits in a genome-wide association study of 299 024 European ancestry individuals, we selected 253 genetic variants to proxy the effect of modifying systolic and diastolic blood pressure. Considering the outcomes of incident coronary artery disease, stroke and the combined outcome of CVD, linear and nonlinear Mendelian randomization analyses were performed on 255 714 European ancestry participants without a history of CVD or antihypertensive medication use. There was no evidence favoring nonlinear relationships of genetically proxied systolic and diastolic blood pressure with the cardiovascular outcomes over linear relationships. For every 10-mm Hg increase in genetically proxied systolic blood pressure, risk of incident CVD increased by 49% (hazard ratio, 1.49 [95% CI, 1.38-1.61]), with similar estimates obtained for coronary artery disease (hazard ratio, 1.50 [95% CI, 1.38-1.63]) and stroke (hazard ratio, 1.44 [95% CI, 1.22-1.70]). Genetically proxied blood pressure had a similar relationship with CVD in men and women. These findings provide evidence to support that even for individuals who do not have elevated blood pressure, public health interventions achieving persistent blood pressure reduction will be of considerable benefit in the primary prevention of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- blood pressure
- coronary artery disease
- hypertension
- primary prevention
- stroke
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Malik, Rainer
-
Georgakis, Mario ...
-
Vujkovic, Marija ...
-
Damrauer, Scott ...
-
Elliott, Paul
-
Karhunen, Ville
-
show more...
-
Giontella, Alice
-
Fava, Cristiano
-
Hellwege, Jackly ...
-
Shuey, Megan M.
-
Edwards, Todd L.
-
Rogne, Tormod
-
Åsvold, Bjørn O.
-
Brumpton, Ben M.
-
Burgess, Stephen
-
Dichgans, Martin
-
Gill, Dipender
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
Hypertension
- By the university
-
Lund University