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Who benefits most f...
Who benefits most from outpatient lifestyle intervention? An IMI-SOPHIA study on pediatric individuals living with overweight and obesity
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- Prinz, Nicole (author)
- German Center for Diabetes Research
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- Pomares-Millan, Hugo (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Dannemann, Almut (author)
- Sana Hospital Lichtenberg
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- Giordano, Giuseppe N. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Joisten, Christine (author)
- German Sport University Cologne
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- Körner, Antje (author)
- University Hospital Leipzig
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- Weghuber, Daniel (author)
- Paracelsus Private Medical University of Salzburg
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- Weihrauch-Blüher, Susann (author)
- Universitätsklinikum Halle
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- Wiegand, Susanna (author)
- Charité - University Medicine Berlin
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- Holl, Reinhard W. (author)
- German Center for Diabetes Research
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- Lanzinger, Stefanie (author)
- German Center for Diabetes Research
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(creator_code:org_t)
- 2023
- 2023
- English 11 s.
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In: Obesity. - 1930-7381. ; 31:9, s. 2375-2385
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Abstract
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- Objective: The first-line approach for childhood obesity is lifestyle intervention (LI); however, success varies. This study aimed first to identify distinct subgroups of response in children living with overweight and obesity and second to elucidate predictors for subclusters. Methods: Based on the obesity patient follow-up registry the APV (Adipositas-Patienten-Verlaufsdokumentation) initiative, a total of 12,453 children and adolescents (median age: 11.5 [IQR: 9.7–13.2] years; BMI z score [BMIz]: 2.06 [IQR: 1.79–2.34]; 52.6% girls) living with overweight/obesity and participating in outpatient LI were studied. Longitudinal k-means clustering was used to identify individual BMIz response curve for up to 2 years after treatment initiation. Multinomial logistic regression was used to elucidate predictors for cluster membership. Results: A total of 36.3% of children and adolescents experienced “no BMIz loss.” The largest subcluster (44.8%) achieved “moderate BMIz loss,” with an average delta-BMIz of −0.23 (IQR: −0.33 to −0.14) at study end. A total of 18.9% had a “pronounced BMIz loss” up to −0.61 (IQR: −0.76 to −0.49). Younger age and lower BMIz at LI initiation, larger initial BMIz loss, and less social deprivation were linked with higher likelihood for moderate or pronounced BMIz loss compared with the no BMIz loss cluster (all p < 0.05). Conclusions: These results support the importance of patient-tailored intervention and earlier treatment escalation in high-risk individuals who have little chance of success.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- art (subject category)
- ref (subject category)
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Obesity
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- By the author/editor
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Prinz, Nicole
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Pomares-Millan, ...
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Dannemann, Almut
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Giordano, Giusep ...
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Joisten, Christi ...
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Körner, Antje
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Weghuber, Daniel
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Weihrauch-Blüher ...
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Wiegand, Susanna
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Holl, Reinhard W ...
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Lanzinger, Stefa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Obesity
- By the university
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Lund University