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Polymorphisms in fa...
Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk
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- Hoeft, Birgit (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Linseisen, Jakob (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Beckmann, Lars (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Mueller-Decker, Karin (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Canzian, Federico (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Huesing, Anika (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- German Cancer Research Center, Heidelberg, Germany
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- Vogel, Ulla (författare)
- National Food Institute, Technical University of Denmark, Soborg, Denmark,National Research Centre for the Working Environment, Copenhagen, Denmark
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- Jakobsen, Marianne U. (författare)
- Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
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- Overvad, Kim (författare)
- Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
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- Hansen, Rikke D. (författare)
- Danish Cancer Society, Copenhagen, Denmark
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- Knueppel, Sven (författare)
- Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
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- Boeing, Heiner (författare)
- Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
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- Trichopoulou, Antonia (författare)
- Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece,Hellenic Health Foundation, Greece
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- Koumantaki, Yvoni (författare)
- Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
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- Trichopoulos, Dimitrios (författare)
- Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
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- Berrino, Franco (författare)
- Etiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
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- Palli, Domenico (författare)
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy
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- Panico, Salvatore (författare)
- Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Unit, Department of Oncology , “Civile - M.P.Arezzo” Hospital, Ragusa, Italy
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- Bueno-de-Mesquita, H. B. (författare)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
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- van Duijnhoven, Franzel J. B. (författare)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
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- van Gils, Carla H. (författare)
- Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
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- Peeters, Petra H. (författare)
- Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
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- Dumeaux, Vanessa (författare)
- Institute of Community Medicine, University of Tromsø, Norway
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- Lund, Eiliv (författare)
- Institute of Community Medicine, University of Tromsø, Norway
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- Huerta Castano, Jose M. (författare)
- CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Council of Health and Consumer Affairs, Murcia, Spain
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- Munoz, Xavier (författare)
- Research Laboratory and Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain
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- Rodriguez, Laudina (författare)
- Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
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- Barricarte, Aurelio (författare)
- CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Public Health Institute of Navarra, Pamplona, Spain
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Department of Surgery, Malmö University Hospital, Malmö, Sweden
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for Molecular Pathology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö Sweden,CREATE Health Center for Translational Cancer Research, Biomedical Center, Lund University, Lund, Sweden
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- Van Guelpen, Bethany (författare)
- Umeå universitet,Patologi
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning
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- Spencer, Elizabeth A. (författare)
- Cancer Epidemiology Unit, University of Oxford, Oxford, UK
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- Crowe, Francesca L. (författare)
- Cancer Epidemiology Unit, University of Oxford, Oxford, UK
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- Khaw, Kay-Tee (författare)
- Department of Public Health and Primary Care, University of Cambridge
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- Wareham, Nick (författare)
- Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK
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- Morois, Sophie (författare)
- Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
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- Boutron-Ruault, Marie-Christine (författare)
- Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
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- Clavel-Chapelon, Francoise (författare)
- Inserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France
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- Chajes, Veronique (författare)
- International Agency for Research on Cancer (IARC), Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC), Lyon, France
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- Boffetta, Paolo (författare)
- International Agency for Research on Cancer (IARC), Lyon, France
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- Vineis, Paolo (författare)
- Cancer Epidemiology Department, University of Turin, Turin, Italy,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
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- Mouw, Traci (författare)
- Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
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- Norat, Teresa (författare)
- Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
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- Riboli, Elio (författare)
- Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK
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- Nieters, Alexandra (författare)
- German Cancer Research Center, Heidelberg, Germany,Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany
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(creator_code:org_t)
- 2009-12-30
- 2010
- Engelska.
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Ingår i: Carcinogenesis. - : Oxford University Press (OUP). - 0143-3334 .- 1460-2180. ; 31:3, s. 466-472
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of > 5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whereas prostaglandin E receptor 2 (PTGER2) was associated with lower CRC risk. A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC. Based on these data, we present for the first time the association of HPGD variants with CRC risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Hoeft, Birgit
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Linseisen, Jakob
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Beckmann, Lars
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Mueller-Decker, ...
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Canzian, Federic ...
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Huesing, Anika
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visa fler...
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Kaaks, Rudolf
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Vogel, Ulla
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Jakobsen, Marian ...
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Overvad, Kim
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Hansen, Rikke D.
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Knueppel, Sven
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Boeing, Heiner
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Trichopoulou, An ...
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Koumantaki, Yvon ...
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Trichopoulos, Di ...
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Berrino, Franco
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Palli, Domenico
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Panico, Salvator ...
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Tumino, Rosario
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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van Gils, Carla ...
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Peeters, Petra H ...
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Dumeaux, Vanessa
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Lund, Eiliv
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Huerta Castano, ...
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Munoz, Xavier
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Rodriguez, Laudi ...
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Barricarte, Aure ...
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Manjer, Jonas
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Jirström, Karin
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Van Guelpen, Bet ...
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Hallmans, Göran, ...
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Spencer, Elizabe ...
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Crowe, Francesca ...
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Khaw, Kay-Tee
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Wareham, Nick
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Morois, Sophie
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Chajes, Veroniqu ...
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Jenab, Mazda
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Boffetta, Paolo
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Vineis, Paolo
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Mouw, Traci
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Norat, Teresa
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Riboli, Elio
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Nieters, Alexand ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Carcinogenesis
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Lunds universitet
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