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Sökning: WFRF:(Van Duijnhoven Franzel J. B.) > Polymorphisms in fa...

  • Hoeft, BirgitGerman Cancer Research Center, Heidelberg, Germany (författare)

Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • 2009-12-30
  • Oxford University Press (OUP),2010

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:4b3a8308-961c-4ff1-97d4-b0ccf1636b9c
  • https://lup.lub.lu.se/record/1589684URI
  • https://doi.org/10.1093/carcin/bgp325DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31571URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Colorectal cancer (CRC) is the third most common malignant tumor and the fourth leading cause of cancer death worldwide. The crucial role of fatty acids for a number of important biological processes suggests a more in-depth analysis of inter-individual differences in fatty acid metabolizing genes as contributing factor to colon carcinogenesis. We examined the association between genetic variability in 43 fatty acid metabolism-related genes and colorectal risk in 1225 CRC cases and 2032 controls participating in the European Prospective Investigation into Cancer and Nutrition study. Three hundred and ninety two single-nucleotide polymorphisms were selected using pairwise tagging with an r(2) cutoff of 0.8 and a minor allele frequency of > 5%. Conditional logistic regression models were used to estimate odds ratios and corresponding 95% confidence intervals. Haplotype analysis was performed using a generalized linear model framework. On the genotype level, hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), phospholipase A2 group VI (PLA2G6) and transient receptor potential vanilloid 3 were associated with higher risk for CRC, whereas prostaglandin E receptor 2 (PTGER2) was associated with lower CRC risk. A significant inverse association (P < 0.006) was found for PTGER2 GGG haplotype, whereas HPGD AGGAG and PLA2G3 CT haplotypes were significantly (P < 0.001 and P = 0.003, respectively) associated with higher risk of CRC. Based on these data, we present for the first time the association of HPGD variants with CRC risk. Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Linseisen, JakobGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Beckmann, LarsGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Mueller-Decker, KarinGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Canzian, FedericoGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Huesing, AnikaGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Kaaks, RudolfGerman Cancer Research Center, Heidelberg, Germany (författare)
  • Vogel, UllaNational Food Institute, Technical University of Denmark, Soborg, Denmark,National Research Centre for the Working Environment, Copenhagen, Denmark (författare)
  • Jakobsen, Marianne U.Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark (författare)
  • Overvad, KimDepartment of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark (författare)
  • Hansen, Rikke D.Danish Cancer Society, Copenhagen, Denmark (författare)
  • Knueppel, SvenDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany (författare)
  • Boeing, HeinerDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany (författare)
  • Trichopoulou, AntoniaDepartment of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece,Hellenic Health Foundation, Greece (författare)
  • Koumantaki, YvoniDepartment of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece (författare)
  • Trichopoulos, DimitriosDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA (författare)
  • Berrino, FrancoEtiological Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy (författare)
  • Palli, DomenicoMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Florence, Italy (författare)
  • Panico, SalvatoreDepartment of Clinical and Experimental Medicine, Federico II University, Naples, Italy (författare)
  • Tumino, RosarioCancer Registry and Histopathology Unit, Department of Oncology , “Civile - M.P.Arezzo” Hospital, Ragusa, Italy (författare)
  • Bueno-de-Mesquita, H. B.National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (författare)
  • van Duijnhoven, Franzel J. B.National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands (författare)
  • van Gils, Carla H.Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands (författare)
  • Peeters, Petra H.Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK (författare)
  • Dumeaux, VanessaInstitute of Community Medicine, University of Tromsø, Norway (författare)
  • Lund, EilivInstitute of Community Medicine, University of Tromsø, Norway (författare)
  • Huerta Castano, Jose M.CIBER Epidemiología y Salud Pública, CIBERESP, Spain,Council of Health and Consumer Affairs, Murcia, Spain (författare)
  • Munoz, XavierResearch Laboratory and Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain (författare)
  • Rodriguez, LaudinaPublic Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain (författare)
  • Barricarte, AurelioCIBER Epidemiología y Salud Pública, CIBERESP, Spain,Public Health Institute of Navarra, Pamplona, Spain (författare)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Department of Surgery, Malmö University Hospital, Malmö, Sweden(Swepub:lu)smi-jma (författare)
  • Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for Molecular Pathology, Department of Laboratory Medicine, Malmö University Hospital, Lund University, Malmö Sweden,CREATE Health Center for Translational Cancer Research, Biomedical Center, Lund University, Lund, Sweden(Swepub:lu)pat-kji (författare)
  • Van Guelpen, BethanyUmeå universitet,Patologi(Swepub:umu)beyvan99 (författare)
  • Hallmans, Göran,1947-Umeå universitet,Näringsforskning(Swepub:umu)goha0001 (författare)
  • Spencer, Elizabeth A.Cancer Epidemiology Unit, University of Oxford, Oxford, UK (författare)
  • Crowe, Francesca L.Cancer Epidemiology Unit, University of Oxford, Oxford, UK (författare)
  • Khaw, Kay-TeeDepartment of Public Health and Primary Care, University of Cambridge (författare)
  • Wareham, NickMedical Research Council (MRC) Epidemiology Unit, Cambridge, UK (författare)
  • Morois, SophieInserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France (författare)
  • Boutron-Ruault, Marie-ChristineInserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France (författare)
  • Clavel-Chapelon, FrancoiseInserm, (Institut National de la Santé et de la Recherche Médicale), and Institut Gustave Roussy, Villejuif, France (författare)
  • Chajes, VeroniqueInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Boffetta, PaoloInternational Agency for Research on Cancer (IARC), Lyon, France (författare)
  • Vineis, PaoloCancer Epidemiology Department, University of Turin, Turin, Italy,Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK (författare)
  • Mouw, TraciDivision of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK (författare)
  • Norat, TeresaDivision of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK (författare)
  • Riboli, ElioDivision of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK (författare)
  • Nieters, AlexandraGerman Cancer Research Center, Heidelberg, Germany,Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany (författare)
  • German Cancer Research Center, Heidelberg, GermanyNational Food Institute, Technical University of Denmark, Soborg, Denmark (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Carcinogenesis: Oxford University Press (OUP)31:3, s. 466-4720143-33341460-2180

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