Cyclophilin-D inhibition in neuroprotection : dawn of a new era of mitochondrial medicine

Uchino, HiroyukiLund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine (author)

Traumatic brain injury and ischemia can result in marked neuronal degeneration and residual impairment of cerebral function. However, no effective pharmacological treatment directed at tissues of the central nervous system (CNS) for acute intervention has been developed. The detailed pathophysiological cascade leading to -neurodegeneration in these conditions has not been elucidated, but cellular calcium overload and mitochondrial dysfunction have been implicated in a wide range of animal models involving degeneration of the CNS. In particular, activation of the calcium-induced mitochondrial permeability transition (mPT) is considered to be a major cause of cell death inferred by the broad and potent neuroprotective effects of -pharmacological inhibitors of mPT, especially modulators of cyclophilin activity and, more specifically, genetic inactivation of the mitochondrial cyclophilin, cyclophilin D. Reviewed are evidence and challenges that could bring on the dawning of mitochondrial medicine aimed at safeguarding energy supply following acute injury to the CNS.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Animals
Arsenicals
Brain Injuries
Calcium
Cyclophilins
Cyclosporine
Enzyme Inhibitors
Humans
Ischemia
Mitochondria
Neuroprotective Agents

Hatakeyama, Kiyoshi (author)
Morota, SaoriLund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-smt (author)
Tanoue, Tadashi (author)
Nishiyama, Takahisa (author)
Usui, Daiki (author)
Taguchi, Chisato (author)
Suzuki, Morika (author)
Hansson, Magnus JLund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups(Swepub:lu)expb-mha (author)
Elmér, EskilLund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups(Swepub:lu)expb-eel (author)
Wallenberg Neurocentrum, LundMedicinska fakulteten (creator_code:org_t)

In:Acta Neurochirurgica. SupplementumVienna : Springer Vienna118, s. 5-3110065-1419

By the author/editor: Uchino, Hiroyuki; Hatakeyama, Kiyo ...; Morota, Saori; Tanoue, Tadashi; Nishiyama, Takah ...; Usui, Daiki; show more...; Taguchi, Chisato; Suzuki, Morika; Hansson, Magnus ...; Elmér, Eskil; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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