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Long-term clinical ...
Long-term clinical outcome of fetal cell transplantation for Parkinson disease : two case reports
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- Kefalopoulou, Zinovia (författare)
- National Hospital for Neurology and Neurosurgery
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- Politis, Marios (författare)
- Imperial College London
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- Piccini, Paola (författare)
- Imperial College London
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- Mencacci, Niccolo (författare)
- University College London
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- Bhatia, Kailash (författare)
- National Hospital for Neurology and Neurosurgery
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- Jahanshahi, Marjan (författare)
- National Hospital for Neurology and Neurosurgery
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- Widner, Håkan (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Rehncrona, Stig (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Brundin, Patrik (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
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- Björklund, Anders (författare)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
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- Lindvall, Olle (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Limousin, Patricia (författare)
- National Hospital for Neurology and Neurosurgery
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- Quinn, Niall (författare)
- National Hospital for Neurology and Neurosurgery
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- Foltynie, Thomas (författare)
- National Hospital for Neurology and Neurosurgery
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(creator_code:org_t)
- American Medical Association (AMA), 2014
- 2014
- Engelska 5 s.
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Ingår i: JAMA Neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 71:1, s. 7-83
- Relaterad länk:
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http://dx.doi.org/10...
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https://jamanetwork....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- IMPORTANCE: Recent advances in stem cell technologies have rekindled an interest in the use of cell replacement strategies for patients with Parkinson disease. This study reports the very long-term clinical outcomes of fetal cell transplantation in 2 patients with Parkinson disease. Such long-term follow-up data can usefully inform on the potential efficacy of this approach, as well as the design of trials for its further evaluation.OBSERVATIONS: Two patients received intrastriatal grafts of human fetal ventral mesencephalic tissue, rich in dopaminergic neuroblasts, as restorative treatment for their Parkinson disease. To evaluate the very long-term efficacy of the grafts, clinical assessments were performed 18 and 15 years posttransplantation. Motor improvements gained gradually over the first postoperative years were sustained up to 18 years posttransplantation, while both patients have discontinued, and remained free of any, pharmacological dopaminergic therapy.CONCLUSIONS AND RELEVANCE: The results from these 2 cases indicate that dopaminergic cell transplantation can offer very long-term symptomatic relief in patients with Parkinson disease and provide proof-of-concept support for future clinical trials using fetal or stem cell therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Corpus Striatum
- Dopaminergic Neurons
- Fetal Tissue Transplantation
- Follow-Up Studies
- Humans
- Levodopa
- Male
- Mesencephalon
- Middle Aged
- Parkinson Disease
- Positron-Emission Tomography
- Time Factors
- Treatment Outcome
- Case Reports
- Journal Article
- Research Support, Non-U.S. Gov't
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kefalopoulou, Zi ...
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Politis, Marios
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Piccini, Paola
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Mencacci, Niccol ...
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Bhatia, Kailash
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Jahanshahi, Marj ...
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Widner, Håkan
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Rehncrona, Stig
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Brundin, Patrik
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Björklund, Ander ...
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Lindvall, Olle
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Limousin, Patric ...
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Quinn, Niall
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Foltynie, Thomas
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- MEDICIN OCH HÄLSOVETENSKAP
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och Neurologi
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JAMA Neurology
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