Search: (WFRF:(Fortin Paul R.)) pers:(Ramos Casals Manuel) >
Economic Evaluation...
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Barber, Megan R.W.University of Calgary
(author)
Economic Evaluation of Damage Accrual in an International Systemic Lupus Erythematosus Inception Cohort Using a Multistate Model Approach
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-11-27
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Wiley,2020
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9 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:4bc2d2f9-cd54-4208-886f-54632a143b8c
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https://lup.lub.lu.se/record/4bc2d2f9-cd54-4208-886f-54632a143b8cURI
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https://doi.org/10.1002/acr.24092DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145197471URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. Annual data on demographics, disease activity, damage (SLICC/American College of Rheumatology Damage Index [SDI]), hospitalizations, medications, dialysis, and selected procedures were collected. Ten-year cumulative costs (Canadian dollars) were estimated by multiplying annual costs associated with each SDI state by the expected state duration using a multistate model. Results: A total of 1,687 patients participated; 88.7% were female, 49.0% were white, mean ± SD age at diagnosis was 34.6 ± 13.3 years, and mean time to follow-up was 8.9 years (range 0.6–18.5 years). Mean annual costs were higher for those with higher SDI scores as follows: $22,006 (Canadian) (95% confidence interval [95% CI] $16,662, $27,350) for SDI scores ≥5 versus $1,833 (95% CI $1,134, $2,532) for SDI scores of 0. Similarly, 10-year cumulative costs were higher for those with higher SDI scores at the beginning of the 10-year interval as follows: $189,073 (Canadian) (95% CI $142,318, $235,827) for SDI scores ≥5 versus $21,713 (95% CI $13,639, $29,788) for SDI scores of 0. Conclusion: Patients with the highest SDI scores incur 10-year cumulative costs that are ~9-fold higher than those with the lowest SDI scores. By estimating the damage trajectory and incorporating annual costs, data on damage can be used to estimate future costs, which is critical knowledge for evaluating the cost-effectiveness of novel therapies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hanly, John G.Dalhousie University
(author)
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Su, LiUniversity of Cambridge
(author)
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Urowitz, Murray B.University of Toronto
(author)
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St. Pierre, Yvan
(author)
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Romero-Diaz, JuanitaInstituto Nacional de Ciencias Médicas y Nutrición
(author)
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Gordon, CarolineUniversity of Birmingham
(author)
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Bae, Sang CheolHanyang University
(author)
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Bernatsky, SashaMcGill University Health Center
(author)
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Wallace, Daniel J.Cedars-Sinai Medical Center
(author)
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Merrill, Joan T.Oklahoma Medical Research Foundation
(author)
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Isenberg, David A.University College London
(author)
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Rahman, AnisurUniversity College London
(author)
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Ginzler, Ellen M.SUNY Downstate Health Sciences University
(author)
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Petri, MichelleJohns Hopkins University School of Medicine
(author)
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Bruce, Ian N.Manchester Academic Health Science Centre
(author)
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Dooley, Mary A.University of North Carolina
(author)
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Fortin, Paul R.Laval University
(author)
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Gladman, Dafna D.University of Toronto
(author)
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Sanchez-Guerrero, JorgeUniversity of Toronto
(author)
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Steinsson, KristjanNational University Hospital of Iceland
(author)
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Ramsey-Goldman, RosalindNorthwestern University
(author)
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Khamashta, Munther A.
(author)
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Aranow, CynthiaFeinstein Institutes for Medical Research
(author)
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Mackay, MegganFeinstein Institutes for Medical Research
(author)
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Alarcón, Graciela S.University of Alabama
(author)
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Manzi, SusanUniversity of Pittsburgh
(author)
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Nived, OlaLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-oni
(author)
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Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)reum-ajo
(author)
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Zoma, Asad A.Hairmyres Hospital
(author)
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van Vollenhoven, Ronald F.Karolinska Institutet
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Ramos-Casals, ManuelHospital Clínic of Barcelona
(author)
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Ruiz-Irastorza, GuillermoHospital de Cruces
(author)
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Lim, S. SamEmory University
(author)
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Kalunian, Kenneth C.University of California, Los Angeles
(author)
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Inanc, MuratIstanbul University
(author)
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Kamen, Diane L.Medical University of South Carolina
(author)
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Peschken, Christine A.University of Manitoba
(author)
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Jacobsen, SørenCopenhagen University Hospital
(author)
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Askanase, AncaIndian Institute of Technology
(author)
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Farewell, VernonUniversity of Cambridge
(author)
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Stoll, Thomas
(author)
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Buyon, JillNew York University
(author)
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Clarke, Ann E.University of Calgary
(author)
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University of CalgaryDalhousie University
(creator_code:org_t)
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In:Arthritis Care and Research: Wiley72:12, s. 1800-18082151-464X2151-4658
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Barber, Megan R. ...
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Hanly, John G.
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Su, Li
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Urowitz, Murray ...
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St. Pierre, Yvan
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Romero-Diaz, Jua ...
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Gordon, Caroline
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Bae, Sang Cheol
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Bernatsky, Sasha
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Wallace, Daniel ...
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Merrill, Joan T.
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Isenberg, David ...
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Rahman, Anisur
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Ginzler, Ellen M ...
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Petri, Michelle
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Bruce, Ian N.
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Dooley, Mary A.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Sanchez-Guerrero ...
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Khamashta, Munth ...
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Aranow, Cynthia
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Mackay, Meggan
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Alarcón, Graciel ...
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Manzi, Susan
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Nived, Ola
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Jönsen, Andreas
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Zoma, Asad A.
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Kalunian, Kennet ...
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christ ...
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Jacobsen, Søren
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Askanase, Anca
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Farewell, Vernon
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Stoll, Thomas
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Buyon, Jill
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Clarke, Ann E.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Arthritis Care a ...
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Lund University
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Karolinska Institutet