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Economic Evaluation...
Economic Evaluation of Damage Accrual in an International Systemic Lupus Erythematosus Inception Cohort Using a Multistate Model Approach
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- Barber, Megan R.W. (författare)
- University of Calgary
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- Hanly, John G. (författare)
- Dalhousie University
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- Su, Li (författare)
- University of Cambridge
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- Urowitz, Murray B. (författare)
- University of Toronto
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St. Pierre, Yvan (författare)
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- Romero-Diaz, Juanita (författare)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Gordon, Caroline (författare)
- University of Birmingham
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- Bae, Sang Cheol (författare)
- Hanyang University
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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- Wallace, Daniel J. (författare)
- Cedars-Sinai Medical Center
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Isenberg, David A. (författare)
- University College London
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- Rahman, Anisur (författare)
- University College London
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- Ginzler, Ellen M. (författare)
- SUNY Downstate Health Sciences University
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- Petri, Michelle (författare)
- Johns Hopkins University School of Medicine
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- Bruce, Ian N. (författare)
- Manchester Academic Health Science Centre
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- Dooley, Mary A. (författare)
- University of North Carolina
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- Fortin, Paul R. (författare)
- Laval University
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- Gladman, Dafna D. (författare)
- University of Toronto
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- Sanchez-Guerrero, Jorge (författare)
- University of Toronto
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- Steinsson, Kristjan (författare)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University
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Khamashta, Munther A. (författare)
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- Aranow, Cynthia (författare)
- Feinstein Institutes for Medical Research
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- Mackay, Meggan (författare)
- Feinstein Institutes for Medical Research
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- Alarcón, Graciela S. (författare)
- University of Alabama
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- Manzi, Susan (författare)
- University of Pittsburgh
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Zoma, Asad A. (författare)
- Hairmyres Hospital
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- van Vollenhoven, Ronald F. (författare)
- Karolinska Institutet
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- Ramos-Casals, Manuel (författare)
- Hospital Clínic of Barcelona
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- Ruiz-Irastorza, Guillermo (författare)
- Hospital de Cruces
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- Lim, S. Sam (författare)
- Emory University
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- Kalunian, Kenneth C. (författare)
- University of California, Los Angeles
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- Inanc, Murat (författare)
- Istanbul University
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Peschken, Christine A. (författare)
- University of Manitoba
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- Jacobsen, Søren (författare)
- Copenhagen University Hospital
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- Askanase, Anca (författare)
- Indian Institute of Technology
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- Farewell, Vernon (författare)
- University of Cambridge
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Stoll, Thomas (författare)
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- Buyon, Jill (författare)
- New York University
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- Clarke, Ann E. (författare)
- University of Calgary
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(creator_code:org_t)
- 2020-11-27
- 2020
- Engelska 9 s.
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Ingår i: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 72:12, s. 1800-1808
- Relaterad länk:
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http://dx.doi.org/10...
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http://pure-oai.bham...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. Annual data on demographics, disease activity, damage (SLICC/American College of Rheumatology Damage Index [SDI]), hospitalizations, medications, dialysis, and selected procedures were collected. Ten-year cumulative costs (Canadian dollars) were estimated by multiplying annual costs associated with each SDI state by the expected state duration using a multistate model. Results: A total of 1,687 patients participated; 88.7% were female, 49.0% were white, mean ± SD age at diagnosis was 34.6 ± 13.3 years, and mean time to follow-up was 8.9 years (range 0.6–18.5 years). Mean annual costs were higher for those with higher SDI scores as follows: $22,006 (Canadian) (95% confidence interval [95% CI] $16,662, $27,350) for SDI scores ≥5 versus $1,833 (95% CI $1,134, $2,532) for SDI scores of 0. Similarly, 10-year cumulative costs were higher for those with higher SDI scores at the beginning of the 10-year interval as follows: $189,073 (Canadian) (95% CI $142,318, $235,827) for SDI scores ≥5 versus $21,713 (95% CI $13,639, $29,788) for SDI scores of 0. Conclusion: Patients with the highest SDI scores incur 10-year cumulative costs that are ~9-fold higher than those with the lowest SDI scores. By estimating the damage trajectory and incorporating annual costs, data on damage can be used to estimate future costs, which is critical knowledge for evaluating the cost-effectiveness of novel therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- Av författaren/redakt...
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Barber, Megan R. ...
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Hanly, John G.
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Su, Li
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Urowitz, Murray ...
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St. Pierre, Yvan
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Romero-Diaz, Jua ...
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visa fler...
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Gordon, Caroline
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Bae, Sang Cheol
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Bernatsky, Sasha
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Wallace, Daniel ...
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Merrill, Joan T.
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Isenberg, David ...
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Rahman, Anisur
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Ginzler, Ellen M ...
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Petri, Michelle
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Bruce, Ian N.
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Dooley, Mary A.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Sanchez-Guerrero ...
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Khamashta, Munth ...
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Aranow, Cynthia
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Mackay, Meggan
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Alarcón, Graciel ...
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Manzi, Susan
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Nived, Ola
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Jönsen, Andreas
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Zoma, Asad A.
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Kalunian, Kennet ...
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Inanc, Murat
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Kamen, Diane L.
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Peschken, Christ ...
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Jacobsen, Søren
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Askanase, Anca
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Farewell, Vernon
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Stoll, Thomas
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Buyon, Jill
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Clarke, Ann E.
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Lunds universitet
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