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  • Radhoe, Sumant P.Erasmus University Medical Center (author)

How does age affect outcomes after left ventricular assist device implantation : results from the PCHF-VAD registry

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-12-02
  • Wiley,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4be488c0-f53a-4955-be6a-4d7233826d65
  • https://lup.lub.lu.se/record/4be488c0-f53a-4955-be6a-4d7233826d65URI
  • https://doi.org/10.1002/ehf2.14247DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151873155URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into those <50, 50–64, and ≥65 years old. The primary endpoint was all-cause mortality. Among secondary outcomes were heart failure (HF) hospitalizations, right ventricular (RV) failure, haemocompatibility score, bleeding events, non-fatal thromboembolic events, and device-related infections. Of 562 patients, 184 (32.7%) were <50, 305 (54.3%) were aged 50–64, whereas 73 (13.0%) were ≥65 years old. Median follow-up was 1.1 years. Patients in the oldest age group were significantly more often designated as destination therapy (DT) candidates (61%). A 10 year increase in age was associated with a significantly higher risk of mortality (hazard ratio [HR] 1.34, 95% confidence interval [CI] [1.15–1.57]), intracranial bleeding (HR 1.49, 95% CI [1.10–2.02]), and non-intracranial bleeding (HR 1.30, 95% CI [1.09–1.56]), which was confirmed by a higher mean haemocompatibility score (1.37 vs. 0.77, oldest vs. youngest groups, respectively, P = 0.033). Older patients suffered from less device-related infections requiring systemic antibiotics. No age-related differences were observed in HF-related hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, or RV failure. Conclusions: In the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population. The risks of HF hospitalizations, pump thrombosis, ventricular arrhythmia, or RV failure were comparable. Strikingly, older patients had less device-related infections.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Veenis, Jesse F.Erasmus University Medical Center (author)
  • Jakus, NinaUniversity Hospital of Infectious Diseases (author)
  • Timmermans, PhilippeUniversity Hospitals Leuven (author)
  • Pouleur, Anne CatherineCatholic University of Louvain,Saint-Luc University Hospital (author)
  • Rubís, PawelJagiellonian University (author)
  • Van Craenenbroeck, Emeline M.Antwerp University Hospital (author)
  • Gaizauskas, EdvinasVilnius University (author)
  • Barge-Caballero, EduardoHospital Juan Canalejo (author)
  • Paolillo, StefaniaUniversity of Naples Federico II (author)
  • Grundmann, Sebastian (author)
  • D'Amario, DomenicoPoliclinico Universitario Agostino Gemelli (author)
  • Braun, OscarLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-oos (author)
  • Gkouziouta, AggelikiOnassis Cardiac Surgery Center, Athens (author)
  • Planinc, IvoUniversity Hospital of Infectious Diseases (author)
  • Samardzic, JureUniversity Hospital of Infectious Diseases (author)
  • Meyns, BartUniversity Hospitals Leuven (author)
  • Droogne, WalterUniversity Hospitals Leuven (author)
  • Wierzbicki, KarolJagiellonian University (author)
  • Holcman, KatarzynaJagiellonian University (author)
  • Flammer, Andreas J.University Hospital of Zurich (author)
  • Gasparovic, HrvojeUniversity Hospital of Infectious Diseases (author)
  • Biocina, BojanUniversity Hospital of Infectious Diseases (author)
  • Lund, Lars H.Karolinska Institutet,Karolinska Institute (author)
  • Milicic, DavorUniversity Hospital of Infectious Diseases (author)
  • Ruschitzka, FrankUniversity Hospital of Zurich (author)
  • Cikes, MajaUniversity Hospital of Infectious Diseases (author)
  • Brugts, Jasper J.Erasmus University Medical Center (author)
  • Erasmus University Medical CenterUniversity Hospital of Infectious Diseases (creator_code:org_t)

Related titles

  • In:ESC Heart Failure: Wiley10:2, s. 884-8942055-5822

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