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How does age affect...
How does age affect outcomes after left ventricular assist device implantation : results from the PCHF-VAD registry
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- Radhoe, Sumant P. (författare)
- Erasmus University Medical Center
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- Veenis, Jesse F. (författare)
- Erasmus University Medical Center
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- Jakus, Nina (författare)
- University Hospital of Infectious Diseases
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- Timmermans, Philippe (författare)
- University Hospitals Leuven
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- Pouleur, Anne Catherine (författare)
- Catholic University of Louvain,Saint-Luc University Hospital
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- Rubís, Pawel (författare)
- Jagiellonian University
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- Van Craenenbroeck, Emeline M. (författare)
- Antwerp University Hospital
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- Gaizauskas, Edvinas (författare)
- Vilnius University
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- Barge-Caballero, Eduardo (författare)
- Hospital Juan Canalejo
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- Paolillo, Stefania (författare)
- University of Naples Federico II
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Grundmann, Sebastian (författare)
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- D'Amario, Domenico (författare)
- Policlinico Universitario Agostino Gemelli
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- Braun, Oscar (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Gkouziouta, Aggeliki (författare)
- Onassis Cardiac Surgery Center, Athens
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- Planinc, Ivo (författare)
- University Hospital of Infectious Diseases
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- Samardzic, Jure (författare)
- University Hospital of Infectious Diseases
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- Meyns, Bart (författare)
- University Hospitals Leuven
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- Droogne, Walter (författare)
- University Hospitals Leuven
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- Wierzbicki, Karol (författare)
- Jagiellonian University
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- Holcman, Katarzyna (författare)
- Jagiellonian University
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- Flammer, Andreas J. (författare)
- University Hospital of Zurich
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- Gasparovic, Hrvoje (författare)
- University Hospital of Infectious Diseases
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- Biocina, Bojan (författare)
- University Hospital of Infectious Diseases
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- Lund, Lars H. (författare)
- Karolinska Institutet,Karolinska Institute
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- Milicic, Davor (författare)
- University Hospital of Infectious Diseases
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- Ruschitzka, Frank (författare)
- University Hospital of Zurich
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- Cikes, Maja (författare)
- University Hospital of Infectious Diseases
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- Brugts, Jasper J. (författare)
- Erasmus University Medical Center
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(creator_code:org_t)
- 2022-12-02
- 2023
- Engelska.
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Ingår i: ESC Heart Failure. - : Wiley. - 2055-5822. ; 10:2, s. 884-894
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims: Use of left ventricular assist devices (LVADs) in older patients has increased, and assessing outcomes in older LVAD recipients is important. Therefore, this study aimed to investigate associations between age and outcomes after continuous-flow LVAD (cf-LVAD) implantation. Methods and results: Cf-LVAD patients from the multicentre European PCHF-VAD registry were included and categorized into those <50, 50–64, and ≥65 years old. The primary endpoint was all-cause mortality. Among secondary outcomes were heart failure (HF) hospitalizations, right ventricular (RV) failure, haemocompatibility score, bleeding events, non-fatal thromboembolic events, and device-related infections. Of 562 patients, 184 (32.7%) were <50, 305 (54.3%) were aged 50–64, whereas 73 (13.0%) were ≥65 years old. Median follow-up was 1.1 years. Patients in the oldest age group were significantly more often designated as destination therapy (DT) candidates (61%). A 10 year increase in age was associated with a significantly higher risk of mortality (hazard ratio [HR] 1.34, 95% confidence interval [CI] [1.15–1.57]), intracranial bleeding (HR 1.49, 95% CI [1.10–2.02]), and non-intracranial bleeding (HR 1.30, 95% CI [1.09–1.56]), which was confirmed by a higher mean haemocompatibility score (1.37 vs. 0.77, oldest vs. youngest groups, respectively, P = 0.033). Older patients suffered from less device-related infections requiring systemic antibiotics. No age-related differences were observed in HF-related hospitalizations, ventricular arrhythmias, pump thrombosis, non-fatal thromboembolic events, or RV failure. Conclusions: In the PCHF-VAD registry, higher age was associated with increased risk of mortality, and especially with increased risk of major bleeding, which is particularly relevant for the DT population. The risks of HF hospitalizations, pump thrombosis, ventricular arrhythmia, or RV failure were comparable. Strikingly, older patients had less device-related infections.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Advanced heart failure
- Age
- Destination therapy
- Left ventricular assist devices
- Survival
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Radhoe, Sumant P ...
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Veenis, Jesse F.
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Jakus, Nina
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Timmermans, Phil ...
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Pouleur, Anne Ca ...
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Rubís, Pawel
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visa fler...
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Van Craenenbroec ...
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Gaizauskas, Edvi ...
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Barge-Caballero, ...
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Paolillo, Stefan ...
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Grundmann, Sebas ...
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D'Amario, Domeni ...
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Braun, Oscar
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Gkouziouta, Agge ...
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Planinc, Ivo
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Samardzic, Jure
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Meyns, Bart
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Droogne, Walter
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Wierzbicki, Karo ...
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Holcman, Katarzy ...
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Flammer, Andreas ...
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Gasparovic, Hrvo ...
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Biocina, Bojan
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Lund, Lars H.
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Milicic, Davor
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Ruschitzka, Fran ...
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Cikes, Maja
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Brugts, Jasper J ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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ESC Heart Failur ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet