Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Gage Diane) > (2007) > Genome-wide associa...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Saxena, Richa (author)

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

Article/chapterEnglish2007

Publisher, publication year, extent ...

American Association for the Advancement of Science (AAAS),2007

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:4c3f4bd1-ec53-4b36-a53c-564bc07ba43c
https://lup.lub.lu.se/record/663952URI
https://doi.org/10.1126/science.1142358DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Voight, Benjamin F. (author)
Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-vly (author)
Burtt, Noel P. (author)
de Bakker, Paul I. W. (author)
Chen, Hong (author)
Roix, Jeffrey J. (author)
Kathiresan, Sekar (author)
Hirschhorn, Joel N. (author)
Daly, Mark J. (author)
Hughes, Thomas E. (author)
Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
Altshuler, David (author)
Almgren, PeterLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-pal (author)
Florez, Jose C. (author)
Meyer, Joanne (author)
Ardlie, Kristin (author)
Bengtsson Boström, KristinaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)smi-kb0 (author)
Isomaa, Bo (author)
Lettre, Guillaume (author)
Lindblad, UlfLund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups(Swepub:lu)smi-uli (author)
Lyon, Helen N. (author)
Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
Newton-Cheh, Christopher (author)
Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
Orho-Melander, MarjuLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mor (author)
Råstam, LennartLund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups(Swepub:lu)smi-lra (author)
Speliotes, Elizabeth K. (author)
Taskinen, Marja-Riitta (author)
Tuomi, Tiinamaija (author)
Guiducci, Candace (author)
Berglund, AnnaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-abe (author)
Carlson, JoyceLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-jca (author)
Gianniny, Lauren (author)
Hackett, Rachel (author)
Hall, Liselotte (author)
Holmkvist, JohanLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-jho (author)
Laurila, EsaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-ela (author)
Sjögren, MarketaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Cardiovascular Research - Hypertension(Swepub:lu)endo-msj (author)
Sterner, Maria (author)
Surti, Aarti (author)
Svensson, MargaretaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-msv (author)
Svensson, MalinLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mab (author)
Tewhey, Ryan (author)
Blumenstiel, Brendan (author)
Parkin, Melissa (author)
DeFelice, Matthew (author)
Barry, Rachel (author)
Brodeur, Wendy (author)
Camarata, Jody (author)
Chia, Nancy (author)
Fava, Mary (author)
Gibbons, John (author)
Handsaker, Bob (author)
Healy, Claire (author)
Nguyen, Kieu (author)
Gates, Casey (author)
Sougnez, Carrie (author)
Gage, Diane (author)
Nizzari, Marcia (author)
Gabriel, Stacey B. (author)
Chirn, Gung-Wei (author)
Ma, Qicheng (author)
Parikh, HemangLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-hpa (author)
Richardson, Delwood (author)
Ricke, Darrell (author)
Purcell, Shaun (author)
Genomik, diabetes och endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

In:Science: American Association for the Advancement of Science (AAAS)316:5829, s. 1331-13361095-92030036-8075

Internet link

Find in a library

Science (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Saxena, Richa; Voight, Benjamin ...; Lyssenko, Valeri ...; Burtt, Noel P.; de Bakker, Paul ...; Chen, Hong; show more...; Roix, Jeffrey J.; Kathiresan, Seka ...; Hirschhorn, Joel ...; Daly, Mark J.; Hughes, Thomas E ...; Groop, Leif; Altshuler, David; Almgren, Peter; Florez, Jose C.; Meyer, Joanne; Ardlie, Kristin; Bengtsson Boströ ...; Isomaa, Bo; Lettre, Guillaum ...; Lindblad, Ulf; Lyon, Helen N.; Melander, Olle; Newton-Cheh, Chr ...; Nilsson, Peter; Orho-Melander, M ...; Råstam, Lennart; Speliotes, Eliza ...; Taskinen, Marja- ...; Tuomi, Tiinamaij ...; Guiducci, Candac ...; Berglund, Anna; Carlson, Joyce; Gianniny, Lauren; Hackett, Rachel; Hall, Liselotte; Holmkvist, Johan; Laurila, Esa; Sjögren, Marketa; Sterner, Maria; Surti, Aarti; Svensson, Margar ...; Svensson, Malin; Tewhey, Ryan; Blumenstiel, Bre ...; Parkin, Melissa; DeFelice, Matthe ...; Barry, Rachel; Brodeur, Wendy; Camarata, Jody; Chia, Nancy; Fava, Mary; Gibbons, John; Handsaker, Bob; Healy, Claire; Nguyen, Kieu; Gates, Casey; Sougnez, Carrie; Gage, Diane; Nizzari, Marcia; Gabriel, Stacey ...; Chirn, Gung-Wei; Ma, Qicheng; Parikh, Hemang; Richardson, Delw ...; Ricke, Darrell; Purcell, Shaun; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medicinal Chemis ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Science

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se