WFRF:(Nguyen Helen C)
Search: WFRF:(Nguyen Helen C) > Genome-wide associa...
- 20 of 20
- Previous record
- Next record
- To hitlist
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
- Saxena, Richa (author)
- Voight, Benjamin F. (author)
-
- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
- show more...
- Burtt, Noel P. (author)
- de Bakker, Paul I. W. (author)
- Chen, Hong (author)
- Roix, Jeffrey J. (author)
- Kathiresan, Sekar (author)
- Hirschhorn, Joel N. (author)
- Daly, Mark J. (author)
- Hughes, Thomas E. (author)
- Altshuler, David (author)
- Florez, Jose C. (author)
- Meyer, Joanne (author)
- Ardlie, Kristin (author)
- Isomaa, Bo (author)
- Lettre, Guillaume (author)
- Lyon, Helen N. (author)
- Newton-Cheh, Christopher (author)
- Speliotes, Elizabeth K. (author)
- Taskinen, Marja-Riitta (author)
- Tuomi, Tiinamaija (author)
- Guiducci, Candace (author)
- Gianniny, Lauren (author)
- Hackett, Rachel (author)
- Hall, Liselotte (author)
- Sterner, Maria (author)
- Surti, Aarti (author)
- Tewhey, Ryan (author)
- Blumenstiel, Brendan (author)
- Parkin, Melissa (author)
- DeFelice, Matthew (author)
- Barry, Rachel (author)
- Brodeur, Wendy (author)
- Camarata, Jody (author)
- Chia, Nancy (author)
- Fava, Mary (author)
- Gibbons, John (author)
- Handsaker, Bob (author)
- Healy, Claire (author)
- Nguyen, Kieu (author)
- Gates, Casey (author)
- Sougnez, Carrie (author)
- Gage, Diane (author)
- Nizzari, Marcia (author)
- Gabriel, Stacey B. (author)
- Chirn, Gung-Wei (author)
- Ma, Qicheng (author)
- Richardson, Delwood (author)
- Ricke, Darrell (author)
- Purcell, Shaun (author)
- show less...
- (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2007
- 2007
- English.
- In: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 316:5829, s. 1331-1336
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 20 of 20
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Saxena, Richa
- Voight, Benjamin ...
- Lyssenko, Valeri ...
- Burtt, Noel P.
- de Bakker, Paul ...
- Chen, Hong
- show more...
- Roix, Jeffrey J.
- Kathiresan, Seka ...
- Hirschhorn, Joel ...
- Daly, Mark J.
- Hughes, Thomas E ...
- Groop, Leif
- Altshuler, David
- Almgren, Peter
- Florez, Jose C.
- Meyer, Joanne
- Ardlie, Kristin
- Bengtsson Boströ ...
- Isomaa, Bo
- Lettre, Guillaum ...
- Lindblad, Ulf
- Lyon, Helen N.
- Melander, Olle
- Newton-Cheh, Chr ...
- Nilsson, Peter
- Orho-Melander, M ...
- Råstam, Lennart
- Speliotes, Eliza ...
- Taskinen, Marja- ...
- Tuomi, Tiinamaij ...
- Guiducci, Candac ...
- Berglund, Anna
- Carlson, Joyce
- Gianniny, Lauren
- Hackett, Rachel
- Hall, Liselotte
- Holmkvist, Johan
- Laurila, Esa
- Sjögren, Marketa
- Sterner, Maria
- Surti, Aarti
- Svensson, Margar ...
- Svensson, Malin
- Tewhey, Ryan
- Blumenstiel, Bre ...
- Parkin, Melissa
- DeFelice, Matthe ...
- Barry, Rachel
- Brodeur, Wendy
- Camarata, Jody
- Chia, Nancy
- Fava, Mary
- Gibbons, John
- Handsaker, Bob
- Healy, Claire
- Nguyen, Kieu
- Gates, Casey
- Sougnez, Carrie
- Gage, Diane
- Nizzari, Marcia
- Gabriel, Stacey ...
- Chirn, Gung-Wei
- Ma, Qicheng
- Parikh, Hemang
- Richardson, Delw ...
- Ricke, Darrell
- Purcell, Shaun
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Other Clinical M ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Health Sciences
- and Public Health Gl ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medicinal Chemis ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
- Articles in the publication
- Science
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
