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European Associatio...
European Association of Nuclear Medicine Focus 5 : Consensus on Molecular Imaging and Theranostics in Prostate Cancer
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- Oprea-Lager, Daniela Elena (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- MacLennan, Steven (författare)
- University of Aberdeen
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Briganti, Alberto (författare)
- Vita-Salute San Raffaele University
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- Burger, Irene A. (författare)
- Hospital Baden
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- de Jong, Igle (författare)
- University Medical Center Groningen
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- De Santis, Maria (författare)
- Charité - University Medicine Berlin,Medical University of Vienna
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- Eberlein, Uta (författare)
- University Hospital of Wϋrzburg
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- Emmett, Louise (författare)
- St Vincent's Hospital, Sydney
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- Fizazi, Karim (författare)
- Institut Gustave Roussy
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- Gillessen, Silke (författare)
- Oncology Institute of Southern Switzerland,Università della Svizzera Italiana
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- Herrmann, Ken (författare)
- University of Duisburg-Essen
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- Heskamp, Sandra (författare)
- Radboud University Medical Center
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- Iagaru, Andrei (författare)
- Stanford University Medical Center
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- Jereczek-Fossa, Barbara Alicja (författare)
- European Institute of Oncology,University of Milan
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- Kunikowska, Jolanta (författare)
- Medical University of Warsaw
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- Lam, Marnix (författare)
- University Medical Center Utrecht
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- Nanni, Cristina (författare)
- University of Bologna
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- O'Sullivan, Joe M. (författare)
- Queen's University Belfast,Northern Ireland Cancer Centre
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- Panebianco, Valeria (författare)
- Sapienza University of Rome
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- Sala, Evis (författare)
- Policlinico Universitario Agostino Gemelli
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- Sathekge, Mike (författare)
- Steve Biko Academic Hospital,University of Pretoria
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- Sosnowski, Roman (författare)
- The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
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- Tilki, Derya (författare)
- Koc University,University Medical Center Hamburg-Eppendorf
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- Tombal, Bertrand (författare)
- Saint-Luc University Hospital
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- Treglia, Giorgio (författare)
- University of Lausanne,Università della Svizzera Italiana,Regional Hospital of Lugano
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- Tunariu, Nina (författare)
- Royal Marsden Hospital, London
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- Walz, Jochen (författare)
- Institut Paoli-Calmettes
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- Yakar, Derya (författare)
- University Medical Center Groningen,Antoni Van Leeuwenhoek Hospital
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- Dierckx, Rudi (författare)
- University Medical Center Groningen
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- Sartor, Oliver (författare)
- Tulane University School of Medicine
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- Fanti, Stefano (författare)
- St. Orsola-Malpighi University Hospital
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(creator_code:org_t)
- 2024
- 2024
- Engelska 12 s.
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Ingår i: European Urology. - 0302-2838. ; 85:1, s. 49-60
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging and systemic radioligand therapy, to reach a multidisciplinary consensus on the current state of the art in PCa. Design, setting, and participants: The results of a systematic literature search informed a two-round Delphi process with a panel of 28 PCa experts in medical or radiation oncology, urology, radiology, medical physics, and nuclear medicine. The results were discussed and ratified in a consensus meeting. Outcome measurements and statistical analysis: Forty-eight statements were scored on a Likert agreement scale and six as ranking options. Agreement statements were analysed using the RAND appropriateness method. Ranking statements were analysed using weighted summed scores. Results and limitations: After two Delphi rounds, there was consensus on 42/48 (87.5%) of the statements. The expert panel recommends PSMA PET to be used for staging the majority of patients with unfavourable intermediate and high risk, and for restaging of suspected recurrent PCa. There was consensus that oligometastatic disease should be defined as up to five metastases, even using advanced imaging modalities. The group agreed that [177Lu]Lu-PSMA should not be administered only after progression to cabazitaxel and that [223Ra]RaCl2 remains a valid therapeutic option in bone-only metastatic castration-resistant PCa. Uncertainty remains on various topics, including the need for concordant findings on both [18F]FDG and PSMA PET prior to [177Lu]Lu-PSMA therapy. Conclusions: There was a high proportion of agreement among a panel of experts on the use of molecular imaging and theranostics in PCa. Although consensus statements cannot replace high-certainty evidence, these can aid in the interpretation and dissemination of best practice from centres of excellence to the wider clinical community. Patient summary: There are situations when dealing with prostate cancer (PCa) where both the doctors who diagnose and track the disease development and response to treatment, and those who give treatments are unsure about what the best course of action is. Examples include what methods they should use to obtain images of the cancer and what to do when the cancer has returned or spread. We reviewed published research studies and provided a summary to a panel of experts in imaging and treating PCa. We also used the research summary to develop a questionnaire whereby we asked the experts to state whether or not they agreed with a list of statements. We used these results to provide guidance to other health care professionals on how best to image men with PCa and what treatments to give, when, and in what order, based on the information the images provide.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Molecular hybrid imaging
- Nuclear medicine
- Prostate cancer
- Systemic radioligand therapy
- Theranostics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Oprea-Lager, Dan ...
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MacLennan, Steve ...
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Bjartell, Anders
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Briganti, Albert ...
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Burger, Irene A.
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de Jong, Igle
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De Santis, Maria
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Eberlein, Uta
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Emmett, Louise
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Fizazi, Karim
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Gillessen, Silke
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Herrmann, Ken
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Heskamp, Sandra
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Iagaru, Andrei
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Jereczek-Fossa, ...
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Kunikowska, Jola ...
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Lam, Marnix
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Nanni, Cristina
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O'Sullivan, Joe ...
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Panebianco, Vale ...
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Sala, Evis
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Sathekge, Mike
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Sosnowski, Roman
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Tilki, Derya
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Tombal, Bertrand
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Treglia, Giorgio
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Tunariu, Nina
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Walz, Jochen
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Yakar, Derya
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Dierckx, Rudi
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Sartor, Oliver
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Fanti, Stefano
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och Urologi och njur ...
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European Urology
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