SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Heesom Kate)
 

Search: WFRF:(Heesom Kate) > (2018) > Epistasis analysis ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Yokoyama, MahoUniversity of Bath (author)

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-07-18
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4cfcd5ab-42e7-4089-8704-d06ab0fdd517
  • https://lup.lub.lu.se/record/4cfcd5ab-42e7-4089-8704-d06ab0fdd517URI
  • https://doi.org/10.1186/s13059-018-1469-2DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important antibiotic mupirocin, have been reported as being cost-free, which suggests that there are few barriers preventing their global spread. However, this is not supported by surveillance data in healthy communities, which indicate that this resistance mechanism is relatively unsuccessful. Results: Epistasis analysis on two collections of MRSA provides an explanation for this discord, where the mupirocin resistance-conferring mutation of the ileS gene appears to affect the levels of toxins produced by S. aureus when combined with specific polymorphisms at other loci. Proteomic analysis demonstrates that the activity of the secretory apparatus of the PSM family of toxins is affected by mupirocin resistance. As an energetically costly activity, this reduction in toxicity masks the fitness costs associated with this resistance mutation, a cost that becomes apparent when toxin production becomes necessary. This hidden fitness cost provides a likely explanation for why this mupirocin-resistance mechanism is not more prevalent, given the widespread use of this antibiotic. Conclusions: With dwindling pools of antibiotics available for use, information on the fitness consequences of the acquisition of resistance may need to be considered when designing antibiotic prescribing policies. However, this study suggests there are levels of depth that we do not understand, and that holistic, surveillance and functional genomics approaches are required to gain this crucial information.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Stevens, EmilyUniversity of Bristol (author)
  • Laabei, MaisemLund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups(Swepub:lu)ma3632la (author)
  • Bacon, LeannUniversity of Bristol (author)
  • Heesom, KateUniversity of Bristol (author)
  • Bayliss, SionUniversity of Bath (author)
  • Ooi, NicolaUniversity of Leeds (author)
  • O'Neill, Alex J.University of Leeds (author)
  • Murray, EwanUniversity of Nottingham (author)
  • Williams, PaulUniversity of Nottingham (author)
  • Lubben, AnnekeUniversity of Bath (author)
  • Reeksting, ShaunUniversity of Bath (author)
  • Meric, GuillaumeUniversity of Bath (author)
  • Pascoe, BenUniversity of Bath (author)
  • Sheppard, Samuel K.University of Bath (author)
  • Recker, MarioUniversity of Exeter (author)
  • Hurst, Laurence D.University of Bath (author)
  • Massey, Ruth C.University of Bristol (author)
  • University of BathUniversity of Bristol (creator_code:org_t)

Related titles

  • In:Genome Biology: Springer Science and Business Media LLC19:11474-75961474-760X

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view