Search: id:"swepub:oai:lup.lub.lu.se:4d2badf6-1890-408d-8b5f-abad52f4c4b3" >
MTA1, a transcripti...
MTA1, a transcriptional activator of breast cancer amplified sequence 3
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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2006-04-25
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Proceedings of the National Academy of Sciences,2006
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LIBRIS-ID:oai:lup.lub.lu.se:4d2badf6-1890-408d-8b5f-abad52f4c4b3
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https://lup.lub.lu.se/record/410255URI
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https://doi.org/10.1073/pnas.0601989103DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor alpha (ER alpha), as a transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3), a gene amplified and overexpressed in breast cancers. We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen. MTA1 stimulation of BCAS3 transcription required ERa and involved a functional ERE half-site in BCAS3. Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase 11 complex to the BCAS3 enhancer sequence. BCAS3 expression was elevated in mammary tumors from MTA1 transgenic mice and 60% of the human breast tumors, and correlated with the coexpression of MTA1 as well as with tumor grade and proliferation of primary breast tumor samples. These findings reveal a previously unrecognized function of MTA1 in stimulating BCAS3 expression and suggest an important role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells.
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Singh, RR
(author)
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Rayala, SK
(author)
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Wigerup, CarolineLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-cho
(author)
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den Hollander, P
(author)
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Zhang, H
(author)
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Balasenthil, S
(author)
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Talukder, AH
(author)
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Landberg, GöranLund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups(Swepub:lu)pat-gla
(author)
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Kumar, R
(author)
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Patologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences103:17, s. 6670-66751091-64900027-8424
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Gururaj, AE
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Singh, RR
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Rayala, SK
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Wigerup, Carolin ...
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den Hollander, P
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Zhang, H
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Balasenthil, S
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Talukder, AH
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Landberg, Göran
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Kumar, R
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Lund University