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Growth and risk for...
Growth and risk for islet autoimmunity and progression to type 1 diabetes in early childhood : The environmental determinants of diabetes in the young study
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- Larsson, Helena Elding (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Vehik, Kendra (author)
- University of South Florida
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- Haller, Michael J. (author)
- University of Florida
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- Liu, Xiang (author)
- University of South Florida
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- Akolkar, Beena (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Hagopian, William (author)
- Pacific Northwest Research Institute
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- Krischer, Jeffrey (author)
- University of South Florida
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- She, Jin Xiong (author)
- Medical College of Georgia
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- Simell, Olli (author)
- Turku University Hospital
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- Toppari, Jorma (author)
- University of Turku
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- Ziegler, Anette G. (author)
- Klinikum rechts der Isar
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- Rewers, Marian (author)
- University of Colorado
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(creator_code:org_t)
- 2016-03-23
- 2016
- English 8 s.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 65:7, s. 1988-1995
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http://dx.doi.org/10...
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https://diabetes.dia...
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Abstract
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- Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This study explored the relationship between weight or height and development of persistent islet autoimmunity and progression to type 1 diabetes during the first 4 years of life in 7,468 children at genetic risk for type 1 diabetes followed in Finland, Germany, Sweden, and the U.S. Growth data collected every third month were used to estimate individual growth curves by mixed models. Cox proportional hazards models were used to evaluate body size and risk of islet autoimmunity and type 1 diabetes. In the overall cohort, development of islet autoimmunity (n = 575) was related to weight z scores at 12 months (hazard ratio [HR] 1.16 per 1.14 kg in males or per 1.02 kg in females, 95% CI 1.06-1.27, P <0.001, false discovery rate [FDR] = 0.008) but not at 24 or 36 months. A similar relationship was seen between weight z scores and development of multiple islet autoantibodies (1 year: HR 1.21, 95% CI 1.08-1.35, P = 0.001, FDR = 0.008; 2 years: HR 1.18, 95% CI 1.06-1.32, P = 0.004, FDR = 0.02). No association was found between weight or height and type 1 diabetes (n = 169). In conclusion, greater weight in the first years of life was associated with an increased risk of islet autoimmunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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Diabetes
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Larsson, Helena ...
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Vehik, Kendra
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Haller, Michael ...
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Liu, Xiang
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Akolkar, Beena
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Hagopian, Willia ...
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Krischer, Jeffre ...
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Lernmark, Åke
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She, Jin Xiong
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Simell, Olli
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Toppari, Jorma
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Ziegler, Anette ...
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Rewers, Marian
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Lund University