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  • Sørensen, Gitte V.Aarhus University Hospital (author)

Late mortality among survivors of childhood acute lymphoblastic leukemia diagnosed during 1971–2008 in Denmark, Finland, and Sweden : A population-based cohort study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-09-28
  • Wiley,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4dbf15fb-96ad-49ec-9fd5-aca260ca9d03
  • https://lup.lub.lu.se/record/4dbf15fb-96ad-49ec-9fd5-aca260ca9d03URI
  • https://doi.org/10.1002/pbc.29356DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147742393URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objective: Investigate all-cause and cause-specific late mortality after childhood acute lymphoblastic leukemia (ALL) in a population-based Nordic cohort. Methods: From the cancer registries of Denmark, Finland, and Sweden, we identified 3765 five-year survivors of ALL, diagnosed before age 20 during 1971–2008. For each survivor, up to five matched comparison subjects were randomly selected from the general population (n = 18,323). Causes of death were classified as relapse related, health related, and external. Late mortality was evaluated by cumulative incidences of death from 5-year survival date. Mortality hazard ratios (HR) were evaluated with Cox proportional models. Results: Among the survivors, 315 deaths occurred during a median follow-up of 16 years from 5-year survival date (range 0–42). The majority were attributable to relapse (n = 224), followed by second neoplasm (n = 45). Cumulative incidence of all-cause late mortality at 15 years from diagnosis decreased gradually over treatment decades, from 14.4% (95% confidence interval [CI]: 11.6–17.2) for survivors diagnosed during 1971–1981, to 2.5% (95% CI: 1.3–3.7) for those diagnosed during 2002–2008. This was mainly attributable to a reduction in relapse-related deaths decreasing from 13.4% (95% CI: 10.7–16.1) for survivors diagnosed during 1971–1981 to 1.9% (95% CI: 0.9–2.8) for those diagnosed during 2002–2008. Health-related late mortality was low and did not change substantially across treatment decades. Compared to comparison subjects, all-cause mortality HR was 40 (95% CI: 26–61) 5–9 years from diagnosis, and 4.4 (95% CI: 3.4–5.6) ≥10 years from diagnosis. Conclusions: Survivors of ALL have higher late mortality than population comparison subjects. Among the survivors, there was a temporal reduction in risk of death from relapse, without increments in health-related death.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Belmonte, FedericaDanish Cancer Society (author)
  • Erdmann, FriederikeUniversitätsmedizin Mainz,Danish Cancer Society (author)
  • Mogensen, HannaKarolinska Institutet,Karolinska Institute (author)
  • Albieri, VannaDanish Cancer Society (author)
  • Holmqvist, Anna S.Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-as- (author)
  • Madanat-Harjuoja, LauraFinnish Cancer Registry (author)
  • Talbäck, MatsKarolinska Institutet,Karolinska Institute (author)
  • Heyman, Mats M.Karolinska Institute (author)
  • Malila, NeaFinnish Cancer Registry (author)
  • Feychting, MariaKarolinska Institutet,Universitätsmedizin Mainz (author)
  • Schmiegelow, KjeldUniversity of Copenhagen (author)
  • Winther, Jeanette F.Aarhus University Hospital,Danish Cancer Society (author)
  • Hasle, HenrikAarhus University Hospital (author)
  • Aarhus University HospitalDanish Cancer Society (creator_code:org_t)

Related titles

  • In:Pediatric Blood and Cancer: Wiley69:11545-50091545-5017

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