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Age-dependent varia...
Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
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- Gyllenberg, A (author)
- Karolinska Institutet,Karolinska Insitutet, Sweden
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- Asad, Samina (author)
- Karolinska Institutet,Karolinska Insitutet, Sweden,Skåne University Hospital, Sweden
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- Piehl, F (author)
- Karolinska Institutet,Karolinska Insitutet, Sweden
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- Swanberg, Maria (author)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups,Lund University, Sweden
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- Padyukov, Leonid, 1957 (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Van Yserloo, B (author)
- University of Washington, Seattle,University of Washington, USA
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- Rutledge, E A (author)
- Salish Kootenai College,Salish Kootenai Coll, USA
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- McNeney, B (author)
- Simon Fraser University, Canada
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- Graham, J (author)
- Simon Fraser University, Canada
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Skåne University Hospital, Sweden
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- Lindholm, E. (author)
- Skåne University Hospital, Sweden
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- Graff, C. (author)
- Karolinska Institutet,Karolinska Institute, Sweden Karolinska University Hospital Huddinge, Sweden
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- Forsell, C (author)
- Karolinska Institutet,Karolinska Institute, Sweden Karolinska University Hospital Huddinge, Sweden
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- Åkesson, K (author)
- Ryhov County Hospital, Jönköping,Ryhov County Hospital, Sweden,Lund University, Sweden Skåne University Hospital, Sweden
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- Landin-Olsson, Mona (author)
- Skåne University Hospital, Sweden
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- Forsander, Gun, 1951 (author)
- Sahlgrenska Ostra University Hospital, Sweden
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- Ivarsson, S.A. (author)
- Skåne University Hospital, Sweden
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- Larsson, H. (author)
- Skåne University Hospital, Sweden
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- Lindblad, B. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg, Sweden
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Marcus, C (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Lernmark, Åke (author)
- Skåne University Hospital, Sweden University of Washington, WA USA,University of Washington, Seattle
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- Alfredsson, L (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Åkesson, Kristina (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Kockum, I (author)
- Karolinska Institutet,Karolinska Insitutet, Sweden
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- Carlsson, Annelie (author)
- Skåne University Hospital
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- Olsson, Tomas (author)
- Karolinska Institutet,Karolinska Insitutet, Sweden
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- ISSN 1476-5470
- 2012-10-11
- 2012
- English 9 s.
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In: Genes and Immunity. - Stockholm : Springer Science and Business Media LLC. - 1476-5470 .- 1466-4879. ; 76:2, s. 202-203
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Abstract
Subject headings
Close
- The major histocompatibility complex class II transactivator (CIITA) gene (16p13) has been reported to associate with susceptibility to multiple sclerosis, rheumatoid arthritis and myocardial infarction, recently also to celiac disease at genome-wide level. However, attempts to replicate association have been inconclusive. Previously, we have observed linkage to the CIITA region in Scandinavian type 1 diabetes (T1D) families. Here we analyze five Swedish T1D cohorts and a combined control material from previous studies of CIITA. We investigate how the genotype distribution within the CIITA gene varies depending on age, and the association to T1D. Unexpectedly, we find a significant difference in the genotype distribution for markers in CIITA (rs11074932, P=4 × 10(-5) and rs3087456, P=0.05) with respect to age, in the collected control material. This observation is replicated in an independent cohort material of about 2000 individuals (P=0.006, P=0.007). We also detect association to T1D for both markers, rs11074932 (P=0.004) and rs3087456 (P=0.001), after adjusting for age at sampling. The association remains independent of the adjacent T1D risk gene CLEC16A. Our results indicate an age-dependent variation in CIITA allele frequencies, a finding of relevance for the contrasting outcomes of previously published association studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- age
- association
- autoimmunity
- CIITA
- type 1 diabetes (T1D)
- major histocompatibility antigen class 2
- transactivator protein
- adolescent
- adult
- age distribution
- article
- controlled study
- female
- genetic association
- genetic risk
- genetic variability
- genotype
- human
- human tissue
- insulin dependent diabetes mellitus
- major clinical study
- male
- priority journal
- Sweden
- type 1 diabetes (T1D); CIITA; autoimmunity; association; age
- type 1 diabetes (T1D)
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Gyllenberg, A
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Asad, Samina
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Piehl, F
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Swanberg, Maria
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Padyukov, Leonid ...
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Van Yserloo, B
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show more...
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Rutledge, E A
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McNeney, B
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Graham, J
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Orho-Melander, M ...
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Lindholm, E.
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Graff, C.
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Forsell, C
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Åkesson, K
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Landin-Olsson, M ...
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Forsander, Gun, ...
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Ivarsson, S.A.
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Larsson, H.
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Lindblad, B.
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Ludvigsson, John ...
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Marcus, C
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Lernmark, Åke
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Alfredsson, L
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Åkesson, Kristin ...
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Kockum, I
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Carlsson, Anneli ...
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Olsson, Tomas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Genes and Immuni ...
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SCANDINAVIAN JOU ...
- By the university
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Lund University
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Karolinska Institutet
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University of Gothenburg
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Linköping University