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Peripheral Nervous ...
Peripheral Nervous System Disease in Systemic Lupus Erythematosus : Results From an International Inception Cohort Study
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- Hanly, John G. (author)
- Dalhousie University
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- Li, Qiuju (author)
- University of Cambridge
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- Su, Li (author)
- University of Cambridge
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- Urowitz, Murray B. (author)
- Toronto Western Hospital,University of Toronto
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- Gordon, Caroline (author)
- University of Birmingham
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- Bae, Sang Cheol (author)
- Hanyang University
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition,Instituto Nacional de Ciencias Médicas y Nutrición
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- Sanchez-Guerrero, Jorge (author)
- Toronto Western Hospital,University of Toronto
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- Bernatsky, Sasha (author)
- McGill University
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- Clarke, Ann E. (author)
- University of Calgary
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- Wallace, Daniel J. (author)
- Cedars-Sinai Medical Center,University of California, Los Angeles
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- Isenberg, David A. (author)
- University College London,NYU Langone
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- Rahman, Anisur (author)
- University College London
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (author)
- Laval University
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- Gladman, Dafna D. (author)
- Toronto Western Hospital,University of Toronto
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- Bruce, Ian N. (author)
- University of Manchester
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University,Feinstein Institute for Medical Research
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- Dooley, M A (author)
- University of North Carolina
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- Steinsson, Kristjan (author)
- National University Hospital of Iceland
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Zoma, Asad A. (author)
- Hairmyres Hospital
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- Manzi, Susan (author)
- Allegheny Health Network
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jonsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Khamashta, Munther A. (author)
- St Thomas' Hospital,King's College London
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- Alarcón, Graciela S. (author)
- University of Alabama
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- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- van Vollenhoven, Ronald F. (author)
- Karolinska Institutet,Academic Medical Center of University of Amsterdam (AMC)
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
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- Ramos-Casals, Manuel (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona
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- Lim, Sung Sam (author)
- Emory University
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- Inanc, Murat (author)
- Istanbul University
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- Kalunian, Kenneth C. (author)
- University of California, San Diego
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- Jacobsen, Soren (author)
- Copenhagen University Hospital
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- Peschken, Christine A. (author)
- University of Manitoba
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Askanase, Anca (author)
- NYU Langone
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- Theriault, Chris (author)
- Dalhousie University
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- Farewell, Vernon (author)
- University of Cambridge
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(creator_code:org_t)
- 2019-11-28
- 2020
- English.
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In: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 72:1, s. 67-77
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Objective: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. Results: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy. Conclusion: PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hanly, John G.
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Li, Qiuju
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Su, Li
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Urowitz, Murray ...
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Gordon, Caroline
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Bae, Sang Cheol
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show more...
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Clarke, Ann E.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M ...
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Dooley, M A
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Steinsson, Krist ...
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Ramsey-Goldman, ...
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Zoma, Asad A.
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Manzi, Susan
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Nived, Ola
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Jonsen, Andreas
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Khamashta, Munth ...
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Alarcón, Graciel ...
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Svenungsson, Eli ...
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van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Ramos-Casals, Ma ...
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Lim, Sung Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Theriault, Chris
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Farewell, Vernon
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Arthritis and Rh ...
- By the university
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Lund University
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Karolinska Institutet