Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.

• Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer's disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebrain cholinergic neurons in AD animal models. Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)

SOCIAL SCIENCES  -- Psychology (hsv//eng)

Keyword

Aged

Aged

80 and over

Alzheimer Disease

drug therapy

Autopsy

Biopsy

Cell Line

Cerebral Cortex

pathology

Cognition

physiology

Dose-Response Relationship

Drug

Electroencephalography

Feasibility Studies

Female

Humans

Infusion Pumps

Implantable

adverse effects

Magnetic Resonance Imaging

Male

Middle Aged

Nerve Growth Factors

administration & dosage

pharmacokinetics

therapeutic use

Neuropsychological Tests

Neurosurgical Procedures

Nicotine

pharmacokinetics

Positron-Emission Tomography

Prosencephalon

physiology

Receptors

Nicotinic

metabolism

Treatment Outcome

nerve growth factor

Psychology

Psychology

Publication and Content Type

ref (subject category)

art (subject category)