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Malignancies in pat...
Malignancies in patients with anti-RNA polymerase III antibodies and systemic sclerosis : Analysis of the EULAR scleroderma trials and research cohort and possible recommendations for screening
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- Lazzaroni, Maria Grazia (författare)
- University of Brescia
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- Cavazzana, Ilaria (författare)
- University of Brescia
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- Colombo, Enrico (författare)
- University of Brescia
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- Dobrota, Rucsandra (författare)
- University Hospital of Zurich
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- Hernandez, Jasmin (författare)
- University Hospital of Zurich
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- Hesselstrand, Roger (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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- Varju, Cecilia (författare)
- University of Pécs
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- Nagy, Gabriella (författare)
- University of Pécs
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- Smith, Vanessa (författare)
- Ghent University Hospital
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- Caramaschi, Paola (författare)
- University Hospital Verona
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- Riccieri, Valeria (författare)
- Sapienza University of Rome
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- Hachulla, Eric (författare)
- University of Lille
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- Balbir-Gurman, Alexandra (författare)
- Technion - Israel Institute of Technology
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- Chatelus, Emmanuel (författare)
- University Hospital Of Strasbourg
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- Romanowska-Próchnicka, Katarzyna (författare)
- Medical University of Warsaw
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- Carolina Araújo, Ana (författare)
- Hospital Curry Cabral
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- Distler, Oliver (författare)
- University Hospital of Zurich
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- Allanore, Yannick (författare)
- Paris Descartes University
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- Airo, Paolo (författare)
- University of Brescia
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(creator_code:org_t)
- 2017-01-15
- 2017
- Engelska 9 s.
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Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 44:5, s. 639-647
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.jrheum.or...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Objective. To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients. Methods. (1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included. (2) Case-control study: additional retrospective data, including malignancy history, were queried in 13 participating EUSTAR centers; 158 anti-RNAP3+ cases were compared with 199 local anti-RNAP3- controls, matched for sex, cutaneous subset, disease duration, and age at SSc onset. (3) A Delphi exercise was performed by 82 experts to reach consensus for cancer screening in anti-RNAP3+ patients. Results. In the EUSTAR registry, anti-RNAP3 were associated in multivariable analysis with renal crisis and diffuse cutaneous involvement. In the case-control study, anti-RNAP3 were associated with gastric antral vascular ectasia, rapid progression of skin involvement, and malignancies concomitant to SSc onset (OR 7.38, 95% CI 1.61-33.8). When compared with other anti-RNAP3+ patients, those with concomitant malignancies had older age (p < 0.001) and more frequent diffuse cutaneous involvement (p = 0.008). The Delphi exercise highlighted the need for malignancy screening at the time of diagnosis for anti-RNAP3+ patients and tight followup in the following years. Conclusion. Anti-RNAP3+ patients with SSc have a high risk of concomitant malignancy. These results have implications for clinical practice and suggest regular screening for cancer in anti-RNAP3+ patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Autoantibodies
- Neoplasms
- Scleroderma
- Systemic sclerosis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Lazzaroni, Maria ...
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Cavazzana, Ilari ...
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Colombo, Enrico
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Dobrota, Rucsand ...
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Hernandez, Jasmi ...
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Hesselstrand, Ro ...
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visa fler...
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Varju, Cecilia
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Nagy, Gabriella
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Smith, Vanessa
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Caramaschi, Paol ...
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Riccieri, Valeri ...
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Hachulla, Eric
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Balbir-Gurman, A ...
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Chatelus, Emmanu ...
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Romanowska-Próch ...
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Carolina Araújo, ...
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Distler, Oliver
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Allanore, Yannic ...
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Airo, Paolo
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