SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Gustafsson Göran)
 

Sökning: WFRF:(Gustafsson Göran) > Everolimus Initiati...

Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients : Long-term Follow-up From the Randomized SCHEDULE Study

Gustafsson, Finn (författare)
University of Copenhagen,Copenhagen University Hospital,Rigshosp, Denmark; Univ Copenhagen, Denmark
Andreassen, Arne K. (författare)
Oslo university hospital,Oslo Univ Hosp, Norway,Sahlgrens Univ Hosp, Sweden,Sahlgrenska University Hospital
Andersson, Bert (författare)
Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden
visa fler...
Eiskjær, Hans (författare)
Aarhus University Hospital,Aarhus Univ Hosp, Denmark
Rådegran, Göran (författare)
Lund University,Lunds universitet,Hjärt-lungsjukdom - information, stöd och bemötande,Forskargrupper vid Lunds universitet,Cardiopulmonary disease - information, support and reception,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Lund Univ, Sweden
Gude, Einar (författare)
Oslo university hospital,Oslo Univ Hosp, Norway
Jansson, Kjell, 1956- (författare)
Linköpings universitet,Linköping University,Östergötland County Council,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US
Solbu, Dag (författare)
Novartis Norge AS, Norway
Karason, Kristjan (författare)
Sahlgrenska University Hospital
Arora, Satish (författare)
Oslo university hospital,Oslo Univ Hosp, Norway
Dellgren, Göran (författare)
Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Sweden
Gullestad, Lars (författare)
University of Oslo,Oslo university hospital,Oslo Univ Hosp, Norway; Univ Oslo, Norway; Univ Oslo, Norway
visa färre...
 (creator_code:org_t)
 
LIPPINCOTT WILLIAMS & WILKINS, 2020
2020
Engelska 11 s.
Ingår i: Transplantation. - : LIPPINCOTT WILLIAMS & WILKINS. - 1534-6080 .- 0041-1337. ; 104:1, s. 154-164
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: A calcineurin inhibitor (CNI)-free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described. METHODS: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure CNI (cyclosporine) followed by CNI withdrawal at week 7-11 posttransplant or (2) standard-exposure cyclosporine, both with mycophenolate mofetil and corticosteroids; 95/115 randomized patients were followed up at 5-7 years posttransplant. RESULTS: Mean measured glomerular filtration rate was 74.7 mL/min and 62.4 mL/min with everolimus and CNI, respectively. The mean difference was in favor of everolimus by 11.8 mL/min in the intent-to-treat population (P = 0.004) and 17.2 mL/min in the per protocol population (n = 75; P < 0.001). From transplantation to last follow-up, the incidence of biopsy-proven acute rejection (BPAR) was 77% (37/48) and 66% (31/47) (P = 0.23) with treated BPAR in 50% and 23% (P < 0.01) in the everolimus and CNI groups, respectively; no episode led to hemodynamic compromise. Coronary allograft vasculopathy (CAV) assessed by coronary intravascular ultrasound was present in 53% (19/36) and 74% (26/35) of everolimus- and CNI-treated patients, respectively (P = 0.037). Graft dimensions and function were similar between the groups. Late adverse events were comparable. CONCLUSIONS: These results suggest that de novo heart transplant patients randomized to everolimus and low-dose CNI followed by CNI-free therapy maintain significantly better long-term renal function as well as significantly reduced CAV than patients randomized to standard CNI treatment. Increased BPAR in the everolimus group during year 1 did not impair long-term graft function.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy