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Sökning: L773:0724 4983 OR L773:1433 8726 > (2020-2023) > Pattern, timing and...

Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma

Neves, Joana B. (författare)
Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,Royal Free Hospital
Vanaclocha Saiz, Leyre (författare)
Faculty of Medical Sciences, University College London, London, United Kingdom
Abu-Ghanem, Yasmin (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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Marchetti, Marta (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
Tran-Dang, My Anh (författare)
Department of Pathology, Royal Free London NHS Foundation Trust, London, United Kingdom
El-Sheikh, Soha (författare)
Department of Pathology, Royal Free London NHS Foundation Trust, London, United Kingdom
Barod, Ravi (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
Beisland, Christian (författare)
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Urology, Haukeland University Hospital, Bergen, Norway,University of Bergen
Capitanio, Umberto (författare)
Department of Urology and Division of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Cullen, David (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
Klatte, Tobias (författare)
Department of Urology, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Department of Surgery, University of Cambridge, Cambridge, United Kingdom,Royal Bournemouth Hospital
Ljungberg, Börje, Professor, 1949- (författare)
Umeå universitet,Umeå University,Urologi och andrologi
Mumtaz, Faiz (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
Patki, Prasad (författare)
Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
Stewart, Grant D. (författare)
Department of Surgery, University of Cambridge, Cambridge, United Kingdom
Dabestani, Saeed (författare)
Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urologi,Urological cancer, Malmö,Lund University Research Groups,Urology,Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Malmö, Sweden
Tran, Maxine G.B. (författare)
Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,University College London
Bex, Axel (författare)
Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,University College London
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 (creator_code:org_t)
 
2021-04-13
2021
Engelska.
Ingår i: World Journal of Urology. - : Springer Science and Business Media LLC. - 0724-4983 .- 1433-8726. ; 39:10, s. 3823-3831
Relaterad länk:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Purpose: Currently there are no specific guidelines for the post-operative follow-up of chromophobe renal cell carcinoma (chRCC). We aimed to evaluate the pattern, location and timing of recurrence after surgery for non-metastatic chRCC and establish predictors of recurrence and cancer-specific death. Methods: Retrospective analysis of consecutive surgically treated non-metastatic chRCC cases from the Royal Free London NHS Foundation Trust (UK, 2015–2019) and the international collaborative database RECUR (15 institutes, 2006–2011). Kaplan–Meier curves were plotted. The association between variables of interest and outcomes were analysed using univariate and multivariate Cox proportional hazards regression models with shared frailty for data source. Results: 295 patients were identified. Median follow-up was 58 months. The five and ten-year recurrence-free survival rates were 94.3% and 89.2%. Seventeen patients (5.7%) developed recurrent disease, 13 (76.5%) with distant metastases. 54% of metastatic disease diagnoses involved a single organ, most commonly the bone. Early recurrence (< 24 months) was observed in 8 cases, all staged ≥ pT2b. 30 deaths occurred, of which 11 were attributed to chRCC. Sarcomatoid differentiation was rare (n = 4) but associated with recurrence and cancer-specific death on univariate analysis. On multivariate analysis, UICC/AJCC T-stage ≥ pT2b, presence of coagulative necrosis, and positive surgical margins were predictors of recurrence and cancer-specific death. Conclusion: Recurrence and death after surgically resected chRCC are rare. For completely excised lesions ≤ pT2a without coagulative necrosis or sarcomatoid features, prognosis is excellent. These patients should be reassured and follow-up intensity curtailed.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

Chromophobe renal cell carcinoma
Follow-up
Nephrectomy
Renal cell carcinoma
Survival
Chromophobe renal cell carcinoma

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