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  • Andersson, Cecilia KLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden (author)

Glucose tolerance and beta-cell function in islet autoantibody-positive children recruited to a secondary prevention study.

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-08
  • Hindawi Limited,2013

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:505f2246-cdac-4257-b7cd-53de77a30016
  • https://lup.lub.lu.se/record/3628454URI
  • https://doi.org/10.1111/pedi.12023DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223013URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • AIMS: Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS: In 47 healthy children with GADA and at least one additional islet autoantibody, intravenous glucose tolerance test (IvGTT) and oral glucose tolerance test (OGTT) were performed 8-65 d apart. Hemoglobin A1c, plasma glucose as well as serum insulin and C-peptide were determined at fasting and during IvGTT and OGTT. RESULTS: All children aged median 5.1 (4.0-9.2) yr had autoantibodies to two to six of the beta-cell antigens GAD65, insulin, IA-2, and the three amino acid position 325 variants of the ZnT8 transporter. In total, 20/47 children showed impaired glucose metabolism. Decreased (≤30 μU/mL insulin) first-phase insulin response (FPIR) was found in 14/20 children while 11/20 had impaired glucose tolerance in the OGTT. Five children had both impaired glucose tolerance and FPIR ≤30 μU/mL insulin. Number and levels of autoantibodies were not associated with glucose metabolism, except for an increased frequency (p = 0.03) and level (p = 0.01) of ZnT8QA in children with impaired glucose metabolism. Among the children with impaired glucose metabolism, 13/20 had HLA-DQ2/8, compared to 9/27 of the children with normal glucose metabolism (p = 0.03). CONCLUSION: Secondary prevention studies in children with islet autoantibodies are complicated by variability in baseline glucose metabolism. Evaluation of metabolic control with both IvGTT and OGTT is critical and should be taken into account before randomization. All currently available autoantibody tests should be analyzed, including ZnT8QA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Paediatrics, Lund University, Skåne University Hospital SUS, Lund, Sweden(Swepub:lu)med-acs (author)
  • Cilio, CorradoLund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden(Swepub:lu)endo-cci (author)
  • Cedervall, ElisabethDepartment of Paediatrics, Helsingborg Hospital, Helsingborg, Sweden (author)
  • Ivarsson, StenLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden(Swepub:lu)pedi-siv (author)
  • Jonsdottir, BerglindLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden(Swepub:lu)med-bij (author)
  • Jönsson, BjörnDepartment of Paediatrics, Ystad Hospital, Ystad, Sweden (author)
  • Larsson, KarinLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Paediatrics, Kristianstad Hospital, Kristianstad, Sweden(Swepub:lu)med-kil (author)
  • Neiderud, JanLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Paediatrics, Helsingborg Hospital, Helsingborg, Sweden(Swepub:lu)med-jnu (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden(Swepub:lu)endo-ale (author)
  • Larsson, HelenaLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden(Swepub:lu)pedi-hla (author)
  • Pediatrisk endokrinologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Pediatric Diabetes: Hindawi Limited14:5, s. 341-3491399-543X1399-5448

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