Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity

We examined the association between plasma 25- hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested casecontrol study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentrationwas measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.

Lee, Hye SeungUniversity of South Florida (author)
Frederiksen, BrittniColorado School of Public Health (author)
Erlund, IrisFinnish National Institute for Health and Welfare (author)
Uusitalo, UllaUniversity of South Florida (author)
Yang, JiminUniversity of South Florida (author)
Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
Simell, OlliTurku University Hospital (author)
Toppari, JormaTurku University Hospital,University of Turku (author)
Rewers, MarianUniversity of Colorado (author)
Ziegler, Anette G.German Diabetes Research Institute (author)
She, Jin XiongMedical College of Georgia (author)
Onengut-Gumuscu, SunaUniversity of Virginia (author)
Chen, Wei MinUniversity of Virginia (author)
Rich, Stephen S.University of Virginia (author)
Sundvall, JoukoFinnish National Institute for Health and Welfare (author)
Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases (author)
Krischer, JeffreyUniversity of South Florida (author)
Virtanen, Suvi M.University of Tampere (author)
Hagopian, WilliamPacific Northwest Research Institute (author)
Colorado School of Public HealthUniversity of South Florida (creator_code:org_t)

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.