Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons.

• The highly specific relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity. To test this idea, we used PF stimulation that was either paired or unpaired with CF activity. Conspicuously, unpaired PF stimulation that induced long-lasting, very large increases in the receptive field sizes of Purkinje cells induced long-lasting decreases in receptive field sizes of their afferent interneurons. In contrast, PF stimulation paired with CF activity that induced long-lasting decreases in the receptive fields of Purkinje cells induced long-lasting, large increases in the receptive fields of interneurons. These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Action Potentials : physiology

Axons : ultrastructure

Cats

Dendrites : physiology

Dendrites : ultrastructure

Electric Stimulation

Excitatory Postsynaptic Potentials : physiology

Interneurons : physiology

Interneurons : cytology

Nerve Net : physiology

Mechanoreceptors : physiology

Neural Inhibition : physiology

Neuronal Plasticity : physiology

Olivary Nucleus : cytology

Synaptic Transmission : physiology

Synapses : ultrastructure

Synapses : physiology

Non-U.S. Gov't

Support

Skin : innervation

Reaction Time : physiology

Purkinje Cells : physiology

Olivary Nucleus : physiology

Purkinje Cells : cytology

Afferent Pathways : cytology

Afferent Pathways : physiology

Animal

Axons : physiology

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)