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Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome : A SYSDIET sub-study

Leder, Lena (författare)
University of Oslo,Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway.
Kolehmainen, Marjukka (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
Narverud, Ingunn (författare)
University of Oslo,Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway.
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Dahlman, Ingrid (författare)
Karolinska Institutet,Karolinska Inst, Dept Med H7, Stockholm, Sweden.
Myhrstad, Mari C W (författare)
Oslo Metropolitan University,Oslo & Akershus Univ, Coll Appl Sci, Fac Hlth Sci, Dept Hlth Nutr & Management, Oslo, Norway.,Univ Eastern Finland, Inst Biomed, Kuopio, Finland.
De Mello, Vanessa D. (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
Paananen, Jussi (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
Carlberg, Carsten (författare)
University of Eastern Finland
Schwab, Ursula (författare)
Kuopio University Hospital,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Inst Clin Med, Internal Med, SF-70210 Kuopio, Finland.
Herzig, Karl Heinz (författare)
Poznan University of Medical Sciences,Med Res Ctr, Inst Biomed, Oulu, Finland.;Med Res Ctr, Bioctr Oulu, Oulu, Finland.;Poznan Univ Med Sci, Dept Gastroenterol & Metab, Poznan, Poland.
Cloetens, Lieselotte (författare)
Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.
Ulmius, Matilda (författare)
Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.
Hukkanen, Janne (författare)
Oulu University Hospital,Univ Oulu, Bioctr Oulu, Oulu, Finland.;Univ Oulu, Dept Internal Med, Inst Clin Med, Kajaanintie 50, SF-90220 Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.
Savolainen, Markku J. (författare)
Oulu University Hospital,Univ Oulu, Bioctr Oulu, Oulu, Finland.;Univ Oulu, Dept Internal Med, Inst Clin Med, Kajaanintie 50, SF-90220 Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.
Rosqvist, Fredrik (författare)
Uppsala universitet,Uppsala University,Klinisk nutrition och metabolism
Hermansen, Kjeld (författare)
Aarhus University Hospital,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark.
Dragsted, Lars O. (författare)
University of Copenhagen,Univ Copenhagen, Dept Nutr Exercise & Sport, Copenhagen, Denmark.
Ingibjörg Gunnarsdottir, Gunnarsdottir (författare)
University of Iceland,Natl Univ Hosp Iceland, Univ Iceland & Landspitali, Unit Nutr Res, Reykjavik, Iceland.
Thorsdottir, Inga (författare)
University of Iceland,Natl Univ Hosp Iceland, Univ Iceland & Landspitali, Unit Nutr Res, Reykjavik, Iceland.
Riserus, Ulf (författare)
Uppsala universitet,Uppsala University,Klinisk nutrition och metabolism
Åkesson, Björn (författare)
Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Skåne University Hospital,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.;Skane Univ Hosp, Dept Clin Nutr, Lund, Sweden.
Thoresen, Magne (författare)
University of Oslo,Univ Oslo, Dept Biostat, Oslo, Norway.
Arner, Peter (författare)
Karolinska Institutet,Karolinska Inst, Dept Med H7, Stockholm, Sweden.
Poutanen, Kaisa S. (författare)
University of Eastern Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
Uusitupa, Matti (författare)
Kuopio University Hospital,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland.
Holven, Kirsten B. (författare)
Oslo university hospital,Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway.;Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Norwegian Natl Advisory Unit Familial Hypercholes, N-0450 Oslo, Norway.
Ulven, Stine M. (författare)
Oslo Metropolitan University,Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway.;Oslo & Akershus Univ, Coll Appl Sci, Fac Hlth Sci, Dept Hlth Nutr & Management, Oslo, Norway.
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University of Oslo Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0317 Oslo, Norway (creator_code:org_t)
2016-03-17
2016
Engelska.
Ingår i: Genes & Nutrition. - : Springer Science and Business Media LLC. - 1555-8932 .- 1865-3499. ; 11:1
Relaterad länk:
http://dx.doi.org/10... (free)
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https://genesandnutr...
https://doi.org/10.1...
https://uu.diva-port... (primary) (Raw object)
https://lup.lub.lu.s...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet (ND) can modify the expression of inflammation and lipid metabolism-related genes in peripheral blood mononuclear cells (PBMCs) during a 2-h oral glucose tolerance test (OGTT) in individuals with MetS. Methods: A Nordic multicenter randomized dietary study included subjects (n = 213) with MetS, randomized to a ND group or a control diet (CD) group applying an isocaloric study protocol. In this sub-study, we included subjects (n = 89) from three Nordic centers: Kuopio (n =26), Lund (n = 30), and Oulu (n = 33) with a maximum weight change of ±4 kg, high-sensitivity C-reactive protein concentration ≤10 mg L-1, and baseline body mass index -2. PBMCs were isolated, and the mRNA gene expression analysis was measured by quantitative real-time polymerase chain reaction (qPCR). We analyzed the mRNA expression changes of 44 genes before and after a 2hOGTT at the beginning and the end of the intervention. Results: The healthy ND significantly down-regulated the expression of toll-like receptor 4 (TLR4), interleukin 18 (IL18), and thrombospondin receptor (CD36) mRNA transcripts and significantly up-regulated the expression of peroxisome proliferator-activated receptor delta (PPARD) mRNA transcript after the 2hOGTT compared to the CD. Conclusions: A healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Nyckelord

Metabolic syndrome
mRNA gene expression
Nordic diet
OGTT
PBMCs
mRNA gene expression

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