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Circulating GDF-15 ...
Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis
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- Gohar, Aisha (author)
- University Medical Center Utrecht
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- Gonçalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies,Skåne University Hospital
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- Vrijenhoek, Joyce (author)
- University Medical Center Utrecht
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- Haitjema, Saskia (author)
- University Medical Center Utrecht
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- van Koeverden, Ian (author)
- University Medical Center Utrecht
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- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
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- de Borst, Gert J. (author)
- University Medical Center Utrecht
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- de Vries, Jean-Paul P. M. (author)
- St. Antonius Hospital
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- Pasterkamp, Gerard (author)
- University Medical Center Utrecht
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- den Ruijter, Hester M (author)
- University Medical Center Utrecht
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- Björkbacka, Harry (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - cellulär metabolism och inflammation,Forskargrupper vid Lunds universitet,Cardiovascular Research - Cellular Metabolism and Inflammation,Lund University Research Groups
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- de Jager, Saskia C A (author)
- University Medical Center Utrecht
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 241, s. 430-436
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Abstract
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- Background: Elevated serum levels of growth differentiation factor-15 (GDF-15), is an established risk factor for a range of cardiovascular diseases.We aimed to evaluate the predictive value of plasma GDF-15 as a biomarker for secondary cardiovascular events (CVE) in patients with atherosclerosis undergoing carotid endarterectomy (CEA). Secondly, we determined whether plasma GDF-15 was associated with carotid plaque characteristics. Methods: Circulating GDF-15 levels were determined by Luminex assay in a cohort of 1056 patients from the Athero-Express biobank. Composite endpoint was defined as major CVE, death and peripheral vascular interventions. Findings were validated in 473 patients from the independent Carotid Plaque Imaging Project biobank. Results: GDF-15 levels did not associate with secondary CVE in the total cohort. However, following a significant interaction with sex, it was found to be strongly, independently predictive of secondary CVE in women but not men (quartile 4 vs. quartile 1: HR 3.04 [95% CI 1.35-6.86], p = 0.007 in women vs. HR 0.96 [95% CI 0.66-1.40], p = 0.845 in men). This was also observed in the validation cohort (women: HR 2.28 [95% CI 1.04-5.05], p = 0.041), albeit dependent upon renal function. In addition, GDF-15 was associated with the presence of plaque smooth muscle cells and calcification. Conclusion: High circulating GDF-15 levels are predictive of secondary CVE in women but not in men with carotid atherosclerotic disease undergoing CEA, suggesting a potential use for GDF-15 as a biomarker for secondary prevention in women. Sex differences in the role of GDF-15 in atherosclerotic disease deserve further interest.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Atherosclerosis
- Biomarker
- GDF-15
- Prognosis
- Secondary outcome
- Women
Publication and Content Type
- art (subject category)
- ref (subject category)
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Gohar, Aisha
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Gonçalves, Isabe ...
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Vrijenhoek, Joyc ...
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Haitjema, Saskia
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van Koeverden, I ...
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Nilsson, Jan
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de Borst, Gert J ...
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de Vries, Jean-P ...
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Pasterkamp, Gera ...
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den Ruijter, Hes ...
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Björkbacka, Harr ...
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de Jager, Saskia ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cardiac and Card ...
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Lund University