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Reduced morbidity a...
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Lundgren, MarkusCentral Hospital Kristianstad
(author)
Reduced morbidity at diagnosis and improved glycemic control in children previously enrolled in DiPiS follow-up
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-05-13
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Hindawi Limited,2014
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:50fb293f-4022-48f1-8c9f-2b13c062215f
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https://lup.lub.lu.se/record/4865397URI
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https://doi.org/10.1111/pedi.12151DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Aims/hypothesis: Children participating in longitudinal type 1 diabetes prediction studies were reported to have less severe disease at diabetes diagnosis. Our aim was to investigate children who from birth participated in the Diabetes Prediction in Skane (DiPiS) study for metabolic status at diagnosis and then continued to be followed for 2 yr of regular clinical care. Methods: Children, followed in DiPiS before diagnosis, were compared to children in the same birth cohort, who did not participate in follow-up. Metabolic status, symptoms at diagnosis as well as hemoglobin A1c (HbA1c) and doses of insulin at 3, 6, 12, and 24 months after diagnosis were compared. Results: Children, followed in DiPiS and diagnosed at 2-12 yr of age, had 0.8% (9 mmol/mol) lower HbA1c at diagnosis than those who were not followed (p=0.006). At diagnosis, fewer DiPiS children had symptoms (p=0.014) and ketoacidosis at diagnosis were reduced (2% compared to 18%, p=0.005). During regular clinical care, HbA1c levels for the DiPiS children remained lower both at 12 (0.4% (4 mmol/mol); p=0.009) and 24 months (0.8% (9 mmol/mol) p < 0.001) after diagnosis, despite no difference in total daily insulin between the two groups. Conclusions: Participation in prospective follow-up before diagnosis of type 1 diabetes leads to earlier diagnosis with fewer symptoms, decreased incidence of ketoacidosis as well as better metabolic control up to 2 yr after diagnosis. Our data indicate that metabolic control at the time of diabetes diagnosis is important for early metabolic control possibly affecting the risk of long-term complications.
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Sahlin, ÅsaBlekinge Hospital
(author)
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Svensson, CamillaCentral Hospital Kristianstad(Swepub:lu)ca6415bo
(author)
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Carlsson, AnnelieLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)med-acs
(author)
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Cedervall, ElisabethÄngelholm Hospital
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Jönsson, BjörnYstad Hospital
(author)
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Jönsson, IdaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)med-ihs
(author)
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Larsson, KarinCentral Hospital Kristianstad
(author)
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Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ale
(author)
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Neiderud, JanHelsingborg Hospital(Swepub:lu)med-jnu
(author)
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Vigård, ToreYstad Hospital(Swepub:lu)med-tva
(author)
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Larsson, HelenaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital(Swepub:lu)pedi-hla
(author)
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Central Hospital KristianstadBlekinge Hospital
(creator_code:org_t)
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In:Pediatric Diabetes: Hindawi Limited15:7, s. 494-5011399-543X
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Sahlin, Åsa
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Jönsson, Ida
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Larsson, Karin
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Lernmark, Åke
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Neiderud, Jan
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Larsson, Helena
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