Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations

Larsson, JimLund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH (författare)

There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source–detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.

Liao, PeilangLund University,Gasporox AB (författare)
Lundin, PatrikGasporox AB(Swepub:lu)fysi-pld (författare)
Krite Svanberg, EmilieLund University,Lunds universitet,Lunds lasercentrum, LLC,Annan verksamhet, LTH,Lunds Tekniska Högskola,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Laser Centre, LLC,Other operations, LTH,Faculty of Engineering, LTH,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-ekv (författare)
Swartling, JohannesGasporox AB(Swepub:lu)fysi-jsw (författare)
Lewander Xu, MärtaGasporox AB (författare)
Bood, JoakimLund University,Lunds universitet,Förbränningsfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)forb-jbo (författare)
Andersson-Engels, StefanLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,University College Cork,Tyndall National Institute(Swepub:lu)fysi-san (författare)
FörbränningsfysikFysiska institutionen (creator_code:org_t)

Av författaren/redakt...: Larsson, Jim; Liao, Peilang; Lundin, Patrik; Krite Svanberg, ...; Swartling, Johan ...; Lewander Xu, Mär ...; visa fler...; Bood, Joakim; Andersson-Engels ...; visa färre...

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk labora ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.