Sökning: (WFRF:(Miglio S)) >
Touch Perception Al...
Touch Perception Altered by Chronic Pain and by Opioid Blockade.
-
- Case, Laura K (författare)
- National Center for Complementary and Integrative Health, NIH , Bethesda, Maryland 20892, USA
-
- Čeko, Marta (författare)
- National Center for Complementary and Integrative Health, NIH , Bethesda, Maryland 20892, USA
-
- Gracely, John L (författare)
- National Center for Complementary and Integrative Health, NIH , Bethesda, Maryland 20892, USA
-
visa fler...
-
- Richards, Emily A (författare)
- National Center for Complementary and Integrative Health, NIH , Bethesda, Maryland 20892, USA
-
- Olausson, Håkan (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Centrum för social och affektiv neurovetenskap (CSAN),Medicinska fakulteten,Region Östergötland, Neurofysiologiska kliniken US
-
- Bushnell, M Catherine (författare)
- National Center for Complementary and Integrative Health, NIH , Bethesda, Maryland 20892, USA
-
visa färre...
-
(creator_code:org_t)
- 2016
- 2016
- Engelska.
-
Ingår i: eNeuro. - 2373-2822. ; 3:1
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Touch plays a significant role in human social behavior and social communication, and its rewarding nature has been suggested to involve opioids. Opioid blockade in monkeys leads to increased solicitation and receipt of grooming, suggesting heightened enjoyment of touch. We sought to study the role of endogenous opioids in perception of affective touch in healthy adults and in patients with fibromyalgia, a chronic pain condition shown to involve reduced opioid receptor availability. The pleasantness of touch has been linked to the activation of C-tactile fibers, which respond maximally to slow gentle touch and correlate with ratings of pleasantness. We administered naloxone to patients and healthy controls to directly observe the consequences of µ-opioid blockade on the perceived pleasantness and intensity of touch. We found that at baseline chronic pain patients showed a blunted distinction between slow and fast brushing for both intensity and pleasantness, suggesting reduced C-tactile touch processing. In addition, we found a differential effect of opioid blockade on touch perception in healthy subjects and pain patients. In healthy individuals, opioid blockade showed a trend toward increased ratings of touch pleasantness, while in chronic pain patients it significantly decreased ratings of touch intensity. Further, in healthy individuals, naloxone-induced increase in touch pleasantness was associated with naloxone-induced decreased preference for slow touch, suggesting a possible effect of opioid levels on processing of C-tactile fiber input. These findings suggest a role for endogenous opioids in touch processing, and provide further evidence for altered opioid functioning in chronic pain patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
eNeuro
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas