id:"swepub:oai:lup.lub.lu.se:524dc885-f32a-4e16-8b08-cb5af31b444b"
Sökning: id:"swepub:oai:lup.lub.lu.se:524dc885-f32a-4e16-8b08-cb5af31b444b" > Genes for C4b-bindi...
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- Andersson, AUniversity of Gothenburg (författare)
Genes for C4b-binding protein alpha- and beta-chains (C4BPA and C4BPB) are located on chromosome 1, band 1q32, in humans and on chromosome 13 in rats
- Artikel/kapitelEngelska1990
Förlag, utgivningsår, omfång ...
- 1990
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:524dc885-f32a-4e16-8b08-cb5af31b444b
- https://lup.lub.lu.se/record/524dc885-f32a-4e16-8b08-cb5af31b444bURI
- https://doi.org/10.1007/BF01233199DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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Klassifikation
Anmärkningar
- C4b-binding protein is involved in the regulation of the complement system. It is a multimeric protein composed of seven identical alpha-chains and a single copy of a unique beta-chain. The latter was identified only recently and its structure determined by cDNA cloning. Both subunits in C4b-binding protein belong to the same superfamily of proteins composed predominantly of tandemly arranged short consensus repeats (SCR) approximately 60 amino acid residues in length. The gene for the human alpha-chain is known to be located in a gene cluster on chromosome 1, band 1q32, which is called the regulators of complement activation (RCA) gene cluster. We have used cDNA probes for both alpha- and beta-chains of human C4b-binding protein to localize their genes with an in situ hybridization technique. We find the genes for both chains to be located on chromosome 1, band 1q32, in the human. This suggests that the beta-chain gene is also a member of the RCA gene cluster and that the alpha- and beta-chain genes are located close to each other. The cDNA probes for the alpha- and beta-chains also were used to screen mouse-rat somatic cell hybrids using Southern blotting to localize their genes in the rat. Both the alpha- and beta-chain genes were shown to be located on chromosome 13 in the rat. These are the second and third genes to be located on rat chromosome 13, and the results suggest that the genes for the alpha- and beta-chains together with the gene for coagulation factor V represent a conserved chromosomal region in rat and man.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- Animals
- Carrier Proteins/genetics
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Complement Activation/genetics
- Complement C4b/metabolism
- Complement Inactivator Proteins
- DNA Probes
- Glycoproteins
- Humans
- Hybrid Cells
- Macromolecular Substances
- Mice
- Multigene Family
- Nucleic Acid Hybridization
- Rats
- Receptors, Complement/genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Dahlbäck, BLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klke-bda (författare)
- Hanson, CUniversity of Gothenburg (författare)
- Hillarp, ALund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)klke-ahi (författare)
- Levan, GUniversity of Gothenburg (författare)
- Szpirer, JUniversité Libre de Bruxelles (ULB) (författare)
- Szpirer, CUniversité Libre de Bruxelles (ULB) (författare)
- University of GothenburgKlinisk kemi, Malmö (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Somatic Cell and Molecular Genetics16:5, s. 493-5000740-7750
Internetlänk
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- Somatic Cell and Molecular Genetics (Sök värdpublikationen i LIBRIS)
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- Andersson, A
- Dahlbäck, B
- Hanson, C
- Hillarp, A
- Levan, G
- Szpirer, J
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- Szpirer, C
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