Enrichment of antibiotic resistance genes within bacteriophage populations in saliva samples from individuals undergoing oral antibiotic treatments

Andersson, TildeLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimental Infection Medicine,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups (författare)

Spread of antibiotic resistance is a significant challenge for our modern health care system, and even more so in developing countries with higher prevalence of both infections and resistant bacteria. Faulty usage of antibiotics has been pinpointed as a driving factor in spread of resistant bacteria through selective pressure. However, horizontal gene transfer mediated through bacteriophages may also play an important role in this spread. In a cohort of Tanzanian patients suffering from bacterial infections, we demonstrate significant differences in the oral microbial diversity between infected and non-infected individuals, as well as before and after oral antibiotics treatment. Further, the resistome carried both by bacteria and bacteriophages vary significantly, with blaCTX-M1 resistance genes being mobilized and enriched within phage populations. This may impact how we consider spread of resistance in a biological context, as well in terms of treatment regimes.

Makenga, GeofreyNational Institute for Medical Research Tanga (författare)
Francis, FilbertKarolinska Institutet,Karolinska Institute,National Institute for Medical Research Tanga (författare)
Minja, Daniel T.R.National Institute for Medical Research Tanga (författare)
Overballe-Petersen, SorenDanish Serum Institute, Copenhagen (författare)
Tang, Man Hung EricDanish Serum Institute, Copenhagen(Swepub:lu)med-m-t (författare)
Fuursted, KurtDanish Serum Institute, Copenhagen (författare)
Baraka, VitoNational Institute for Medical Research Tanga (författare)
Lood, RolfLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär patogenes,Forskargrupper vid Lunds universitet,Experimental Infection Medicine,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Pathogenesis,Lund University Research Groups(Swepub:lu)med-rll (författare)
InfektionsmedicinSektion III (creator_code:org_t)

Av författaren/redakt...: Andersson, Tilde; Makenga, Geofrey; Francis, Filbert; Minja, Daniel T. ...; Overballe-Peters ...; Tang, Man Hung E ...; visa fler...; Fuursted, Kurt; Baraka, Vito; Lood, Rolf; visa färre...

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