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Pseudomonas aerugin...
Pseudomonas aeruginosa infection correlates with high MFI donor-specific antibody development following lung transplantation with consequential graft loss and shortened CLAD-free survival
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- Bogyó, Levente Zoltán (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Török, Klára (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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Illés, Zsuzsanna (författare)
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Szilvási, Anikó (författare)
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- Székely, Bálint (författare)
- National Institute of Oncology, Budapest
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- Bohács, Anikó (författare)
- Semmelweis University
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- Pipek, Orsolya (författare)
- National Institute of Oncology, Budapest,Eötvös Loránd University
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- Madurka, Ildikó (författare)
- National Institute of Oncology, Budapest,National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Megyesfalvi, Zsolt (författare)
- Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Rényi-Vámos, Ferenc (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Döme, Balázs (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Semmelweis University,Medical University of Vienna
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- Bogos, Krisztina (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary
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- Gieszer, Balázs (författare)
- National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest
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- Bakos, Eszter (författare)
- National Institute of Oncology, Budapest
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Respiratory Research. - 1465-9921. ; 25:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Donor-specific antibodies (DSAs) are common following lung transplantation (LuTx), yet their role in graft damage is inconclusive. Mean fluorescent intensity (MFI) is the main read-out of DSA diagnostics; however its value is often disregarded when analyzing unwanted post-transplant outcomes such as graft loss or chronic lung allograft dysfunction (CLAD). Here we aim to evaluate an MFI stratification method in these outcomes. Methods: A cohort of 87 LuTx recipients has been analyzed, in which a cutoff of 8000 MFI has been determined for high MFI based on clinically relevant data. Accordingly, recipients were divided into DSA-negative, DSA-low and DSA-high subgroups. Both graft survival and CLAD-free survival were evaluated. Among factors that may contribute to DSA development we analyzed Pseudomonas aeruginosa (P. aeruginosa) infection in bronchoalveolar lavage (BAL) specimens. Results: High MFI DSAs contributed to clinical antibody-mediated rejection (AMR) and were associated with significantly worse graft (HR: 5.77, p < 0.0001) and CLAD-free survival (HR: 6.47, p = 0.019) compared to low or negative MFI DSA levels. Analysis of BAL specimens revealed a strong correlation between DSA status, P. aeruginosa infection and BAL neutrophilia. DSA-high status and clinical AMR were both independent prognosticators for decreased graft and CLAD-free survival in our multivariate Cox-regression models, whereas BAL neutrophilia was associated with worse graft survival. Conclusions: P. aeruginosa infection rates are elevated in recipients with a strong DSA response. Our results indicate that the simultaneous interpretation of MFI values and BAL neutrophilia is a feasible approach for risk evaluation and may help clinicians when to initiate DSA desensitization therapy, as early intervention could improve prognosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- AMR
- BAL
- CLAD
- DSA
- HLA
- Lung transplantation
- Pseudomonas aeruginosa
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bogyó, Levente Z ...
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Török, Klára
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Illés, Zsuzsanna
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Szilvási, Anikó
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Székely, Bálint
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Bohács, Anikó
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visa fler...
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Pipek, Orsolya
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Madurka, Ildikó
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Megyesfalvi, Zso ...
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Rényi-Vámos, Fer ...
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Döme, Balázs
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Bogos, Krisztina
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Gieszer, Balázs
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Bakos, Eszter
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Respiratory Rese ...
- Av lärosätet
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Lunds universitet