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Embedded 3D Printin...
Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs
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- Kajtez, Janko (författare)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Center,Technical University of Denmark
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- Wesseler, Milan Finn (författare)
- Technical University of Denmark
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- Birtele, Marcella (författare)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Khorasgani, Farinaz Riyahi (författare)
- Technical University of Denmark
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- Rylander Ottosson, Daniella (författare)
- Lund University,Lunds universitet,Regenerativ neurofysiologi,Forskargrupper vid Lunds universitet,Regenerative Neurophysiology,Lund University Research Groups
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- Heiskanen, Arto (författare)
- Technical University of Denmark
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- Kamperman, Tom (författare)
- University of Twente
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- Leijten, Jeroen (författare)
- University of Twente
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- Martínez-Serrano, Alberto (författare)
- Autonomous University of Madrid,CSIC Center of Molecular Biology Severo Ochoa (UAM)
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- Larsen, Niels B (författare)
- Technical University of Denmark
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- Angelini, Thomas E (författare)
- University of Florida
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- Parmar, Malin (författare)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Center
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- Lind, Johan U (författare)
- Technical University of Denmark
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- Emnéus, Jenny (författare)
- Technical University of Denmark
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(creator_code:org_t)
- 2022-06-16
- 2022
- Engelska.
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Ingår i: Advanced science (Weinheim, Baden-Wurttemberg, Germany). - : Wiley. - 2198-3844. ; 9:25
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human in vitro models of neural tissue with tunable microenvironment and defined spatial arrangement are needed to facilitate studies of brain development and disease. Towards this end, embedded printing inside granular gels holds great promise as it allows precise patterning of extremely soft tissue constructs. However, granular printing support formulations are restricted to only a handful of materials. Therefore, there has been a need for novel materials that take advantage of versatile biomimicry of bulk hydrogels while providing high-fidelity support for embedded printing akin to granular gels. To address this need, Authors present a modular platform for bioengineering of neuronal networks via direct embedded 3D printing of human stem cells inside Self-Healing Annealable Particle-Extracellular matrix (SHAPE) composites. SHAPE composites consist of soft microgels immersed in viscous extracellular-matrix solution to enable precise and programmable patterning of human stem cells and consequent generation mature subtype-specific neurons that extend projections into the volume of the annealed support. The developed approach further allows multi-ink deposition, live spatial and temporal monitoring of oxygen levels, as well as creation of vascular-like channels. Due to its modularity and versatility, SHAPE biomanufacturing toolbox has potential to be used in applications beyond functional modeling of mechanically sensitive neural constructs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies (hsv//eng)
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Kajtez, Janko
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Wesseler, Milan ...
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Birtele, Marcell ...
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Khorasgani, Fari ...
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Rylander Ottosso ...
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Heiskanen, Arto
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visa fler...
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Kamperman, Tom
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Leijten, Jeroen
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Martínez-Serrano ...
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Larsen, Niels B
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Angelini, Thomas ...
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Parmar, Malin
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Lind, Johan U
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Emnéus, Jenny
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