Search: WFRF:(Kristensen Gunnar B.)
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Examestane in advan...
Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)
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- Lindemann, Kristina (author)
- Oslo University Hospital, Norway
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- Malander, Susanne (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Lund Hospital, Sweden
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- Christensen, Rene D. (author)
- University of Southern Denmark, Denmark
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- Mirza, Mansoor R. (author)
- University of Copenhagen Hospital, Denmark
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- Kristensen, Gunnar B. (author)
- Oslo University Hospital, Norway Oslo University Hospital, Norway
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- Åvall-Lundqvist, Elisabeth (author)
- Karolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US,Karolinska University Hospital, Sweden
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- Vergote, Ignace (author)
- University Hospital Leuven, Belgium University Hospital Leuven, Belgium
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- Rosenberg, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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- Boman, Karin (author)
- University Hospital, Sweden
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- Nordstrom, Britta (author)
- Karolinska University Hospital, Sweden
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(creator_code:org_t)
- 2014-02-05
- 2014
- English.
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 14
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Abstract
Subject headings
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- Background: We evaluated the efficacy and safety of the aromatase inhibitor exemestane in patients with advanced, persistent or recurrent endometrial carcinoma. Methods: We performed an open-label one-arm, two-stage, phase II study of 25 mg of oral exemestane in 51 patients with advanced (FIGO stage III-IV) or relapsed endometrioid endometrial cancer. Patients were stratified into subsets of estrogen receptor (ER) positive and ER negative patients. Results: Recruitment to the ER negative group was stopped prematurely after 12 patients due to slow accrual. In the ER positive patients, we observed an overall response rate of 10%, and a lack of progression after 6 months in 35% of the patients. No responses were registered in the ER negative patients, and all had progressive disease within 6 months. For the total group of patients, the median progression free survival (PFS) was 3.1 months (95% CI: 2.0-4.1). In the ER positive patients the median PFS was 3.8 months (95% CI: 0.7-6.9) and in the ER negative patients it was 2.6 months (95% CI: 2.1-3-1). In the ER positive patients the median overall survival (OS) time was 13.3 months (95% CI: 7.7-18.9), in the ER negative patients the corresponding numbers were 6.1 months (95% CI: 4.1-8.2). Treatment with exemestane was well tolerated. Conclusion: Treatment of estrogen positive advanced or recurrent endometrial cancer with exemestane, an aromatase inhibitor, resulted in a response rate of 10% and lack of progression after 6 months in 35% of the patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Aromatase inhibitor
- Exemestane
- Endometrial cancer
- Treatment
- Phase II
- study
- Aromatase inhibitor; Exemestane; Endometrial cancer; Treatment; Phase II study
- MEDICINE
Publication and Content Type
- art (subject category)
- ref (subject category)
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BMC Cancer
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Lindemann, Krist ...
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Malander, Susann ...
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Christensen, Ren ...
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Mirza, Mansoor R ...
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Kristensen, Gunn ...
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Åvall-Lundqvist, ...
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Vergote, Ignace
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Rosenberg, Per
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Boman, Karin
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Nordstrom, Britt ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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BMC Cancer
- By the university
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Lund University
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Linköping University
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Karolinska Institutet