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Prenatal Metals Exp...
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Lozano, ManuelUniversity of Valencia
(författare)
Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems
- Artikel/kapitelEngelska2024
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:53c9ef3a-86c9-4f77-893b-130ab49f710d
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https://lup.lub.lu.se/record/53c9ef3a-86c9-4f77-893b-130ab49f710dURI
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https://doi.org/10.1007/s12403-023-00585-6DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153511503URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Broberg, KarinKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH(Swepub:lu)kgen-kbr
(författare)
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Soler-Blasco, RaquelCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Riutort-Mayol, Gabriel
(författare)
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Ballester, FerranCIBER Epidemiology and Public Health (CIBERESP),University of Valencia
(författare)
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González, LlúciaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Murcia, Mario
(författare)
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Grimalt, Joan O.CSIC Institute of Environmental Assessment and Water Research (IDAEA)
(författare)
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Gil, FernandoUniversity of Granada
(författare)
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Olmedo, PabloUniversity of Granada
(författare)
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Braeuer, SimoneKarl-Franzens-University of Graz
(författare)
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Casas, MaribelPompeu Fabra University,Centre for Research in Environmental Epidemiology,CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Guxens, MònicaPompeu Fabra University,CIBER Epidemiology and Public Health (CIBERESP),Erasmus University Medical Center,Centre for Research in Environmental Epidemiology
(författare)
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Irizar, AmaiaUniversity of the Basque Country,Biodonostia Health Research Institute
(författare)
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Lertxundi, NereaBiodonostia Health Research Institute,University of the Basque Country
(författare)
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Zubero, Miren BegoñaBiodonostia Health Research Institute,University of the Basque Country
(författare)
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Marina, Loreto SantaMinistry of Health of the Basque Government,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Llop, SabrinaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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University of ValenciaMetalund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Exposure and Health16:3, s. 679-6922451-9766
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Till lärosätets databas
- Av författaren/redakt...
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Lozano, Manuel
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Broberg, Karin
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Soler-Blasco, Ra ...
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Riutort-Mayol, G ...
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Ballester, Ferra ...
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González, Llúcia
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visa fler...
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Murcia, Mario
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Grimalt, Joan O.
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Gil, Fernando
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Olmedo, Pablo
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Braeuer, Simone
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Casas, Maribel
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Guxens, Mònica
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Irizar, Amaia
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Lertxundi, Nerea
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Zubero, Miren Be ...
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Marina, Loreto S ...
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Llop, Sabrina
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visa färre...
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Lunds universitet
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Karolinska Institutet