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Prenatal Metals Exp...
Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems
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- Lozano, Manuel (author)
- University of Valencia
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- Broberg, Karin (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Metalund,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH
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- Soler-Blasco, Raquel (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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Riutort-Mayol, Gabriel (author)
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- Ballester, Ferran (author)
- CIBER Epidemiology and Public Health (CIBERESP),University of Valencia
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- González, Llúcia (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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Murcia, Mario (author)
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- Grimalt, Joan O. (author)
- CSIC Institute of Environmental Assessment and Water Research (IDAEA)
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- Gil, Fernando (author)
- University of Granada
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- Olmedo, Pablo (author)
- University of Granada
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- Braeuer, Simone (author)
- Karl-Franzens-University of Graz
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- Casas, Maribel (author)
- Pompeu Fabra University,Centre for Research in Environmental Epidemiology,CIBER Epidemiology and Public Health (CIBERESP)
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- Guxens, Mònica (author)
- Pompeu Fabra University,CIBER Epidemiology and Public Health (CIBERESP),Erasmus University Medical Center,Centre for Research in Environmental Epidemiology
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- Irizar, Amaia (author)
- University of the Basque Country,Biodonostia Health Research Institute
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- Lertxundi, Nerea (author)
- Biodonostia Health Research Institute,University of the Basque Country
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- Zubero, Miren Begoña (author)
- Biodonostia Health Research Institute,University of the Basque Country
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- Marina, Loreto Santa (author)
- Ministry of Health of the Basque Government,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Llop, Sabrina (author)
- CIBER Epidemiology and Public Health (CIBERESP)
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(creator_code:org_t)
- 2024
- 2024
- English 14 s.
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In: Exposure and Health. - 2451-9766. ; 16:3, s. 679-692
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Arsenic speciation
- Emotional and behavioral problems
- Metals
- Prenatal exposure
- Trace elements
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Lozano, Manuel
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Broberg, Karin
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Soler-Blasco, Ra ...
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Riutort-Mayol, G ...
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Ballester, Ferra ...
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González, Llúcia
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show more...
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Murcia, Mario
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Grimalt, Joan O.
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Gil, Fernando
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Olmedo, Pablo
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Braeuer, Simone
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Casas, Maribel
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Guxens, Mònica
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Irizar, Amaia
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Lertxundi, Nerea
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Zubero, Miren Be ...
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Marina, Loreto S ...
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Llop, Sabrina
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Exposure and Hea ...
- By the university
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Lund University
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Karolinska Institutet