Search: (WFRF:(Turner Mark A)) srt2:(2010-2014) pers:(Offit Kenneth) >
Genome-wide Associa...
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Skibola, Christine F
(author)
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.
- Article/chapterEnglish2014
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:53e478f7-2858-4371-9919-59c067c00ed9
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https://lup.lub.lu.se/record/4738286URI
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https://doi.org/10.1016/j.ajhg.2014.09.004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129828674URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235614URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
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Berndt, Sonja I
(author)
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Vijai, Joseph
(author)
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Conde, Lucia
(author)
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Wang, Zhaoming
(author)
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Yeager, Meredith
(author)
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de Bakker, Paul I W
(author)
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Birmann, Brenda M
(author)
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Vajdic, Claire M
(author)
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Foo, Jia-Nee
(author)
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Bracci, Paige M
(author)
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Vermeulen, Roel C H
(author)
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Slager, Susan L
(author)
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de Sanjose, Silvia
(author)
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Wang, Sophia S
(author)
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Linet, Martha S
(author)
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Salles, Gilles
(author)
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Lan, Qing
(author)
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Severi, Gianluca
(author)
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Hjalgrim, HenrikKarolinska Institutet
(author)
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Lightfoot, Tracy
(author)
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Melbye, Mads
(author)
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Gu, Jian
(author)
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Ghesquières, Hervé
(author)
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Link, Brian K
(author)
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Morton, Lindsay M
(author)
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Holly, Elizabeth A
(author)
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Smith, Alex
(author)
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Tinker, Lesley F
(author)
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Teras, Lauren R
(author)
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Kricker, Anne
(author)
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Becker, Nikolaus
(author)
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Purdue, Mark P
(author)
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Spinelli, John J
(author)
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Zhang, Yawei
(author)
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Giles, Graham G
(author)
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Vineis, Paolo
(author)
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Monnereau, Alain
(author)
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Bertrand, Kimberly A
(author)
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Albanes, Demetrius
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Gabbas, Attilio
(author)
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Chung, Charles C
(author)
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Burdett, Laurie
(author)
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Hutchinson, Amy
(author)
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Lawrence, Charles
(author)
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Montalvan, Rebecca
(author)
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Liang, Liming
(author)
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Huang, Jinyan
(author)
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Ma, Baoshan
(author)
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Liu, Jianjun
(author)
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Adami, Hans-Olov
(author)
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Glimelius, BengtUppsala universitet,Enheten för onkologi(Swepub:uu)bengglim
(author)
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Ye, Yuanqing
(author)
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Nowakowski, Grzegorz S
(author)
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Dogan, Ahmet
(author)
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Thompson, Carrie A
(author)
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Habermann, Thomas M
(author)
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Novak, Anne J
(author)
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Liebow, Mark
(author)
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Witzig, Thomas E
(author)
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Weiner, George J
(author)
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Schenk, Maryjean
(author)
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Hartge, Patricia
(author)
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De Roos, Anneclaire J
(author)
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Cozen, Wendy
(author)
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Zhi, Degui
(author)
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Akers, Nicholas K
(author)
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Riby, Jacques
(author)
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Smith, Martyn T
(author)
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Lacher, Mortimer
(author)
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Villano, Danylo J
(author)
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Maria, Ann
(author)
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Roman, Eve
(author)
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Kane, EleanorKarolinska Institutet
(author)
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Jackson, Rebecca D
(author)
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North, Kari E
(author)
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Diver, W Ryan
(author)
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Turner, Jenny
(author)
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Armstrong, Bruce K
(author)
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Benavente, Yolanda
(author)
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Boffetta, Paolo
(author)
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Brennan, Paul
(author)
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Foretova, Lenka
(author)
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Maynadie, Marc
(author)
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Staines, Anthony
(author)
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McKay, James
(author)
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Brooks-Wilson, Angela R
(author)
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Zheng, Tongzhang
(author)
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Holford, Theodore R
(author)
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Chamosa, Saioa
(author)
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Kaaks, Rudolph
(author)
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Kelly, Rachel S
(author)
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Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)kir-boh
(author)
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Travis, Ruth C
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Clavel, Jacqueline
(author)
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Giovannucci, Edward
(author)
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Kraft, Peter
(author)
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Virtamo, Jarmo
(author)
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Mazza, Patrizio
(author)
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Cocco, Pierluigi
(author)
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Ennas, Maria Grazia
(author)
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Chiu, Brian C H
(author)
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Fraumeni, Joseph F
(author)
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Nieters, Alexandra
(author)
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Offit, Kenneth
(author)
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Wu, Xifeng
(author)
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Cerhan, James R
(author)
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Smedby, Karin E
(author)
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Chanock, Stephen J
(author)
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Rothman, Nathaniel
(author)
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Karolinska InstitutetEnheten för onkologi
(creator_code:org_t)
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In:American Journal of Human Genetics: Elsevier BV95:4, s. 462-4710002-92971537-6605
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- By the author/editor
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Skibola, Christi ...
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Berndt, Sonja I
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Vijai, Joseph
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Conde, Lucia
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Wang, Zhaoming
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Yeager, Meredith
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show more...
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de Bakker, Paul ...
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Birmann, Brenda ...
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Vajdic, Claire M
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Foo, Jia-Nee
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Bracci, Paige M
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Vermeulen, Roel ...
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Slager, Susan L
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de Sanjose, Silv ...
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Wang, Sophia S
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Linet, Martha S
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Salles, Gilles
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Lan, Qing
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Severi, Gianluca
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Hjalgrim, Henrik
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Lightfoot, Tracy
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Melbye, Mads
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Gu, Jian
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Ghesquières, Her ...
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Link, Brian K
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Morton, Lindsay ...
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Holly, Elizabeth ...
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Smith, Alex
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Tinker, Lesley F
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Teras, Lauren R
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Kricker, Anne
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Becker, Nikolaus
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Purdue, Mark P
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Spinelli, John J
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Zhang, Yawei
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Giles, Graham G
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Vineis, Paolo
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Monnereau, Alain
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Bertrand, Kimber ...
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Albanes, Demetri ...
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Zeleniuch-Jacquo ...
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Gabbas, Attilio
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Chung, Charles C
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Burdett, Laurie
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Hutchinson, Amy
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Lawrence, Charle ...
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Montalvan, Rebec ...
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Liang, Liming
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Huang, Jinyan
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Ma, Baoshan
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Liu, Jianjun
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Adami, Hans-Olov
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Glimelius, Bengt
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Ye, Yuanqing
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Nowakowski, Grze ...
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Dogan, Ahmet
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Thompson, Carrie ...
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Habermann, Thoma ...
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Novak, Anne J
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Liebow, Mark
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Witzig, Thomas E
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Weiner, George J
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Schenk, Maryjean
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Hartge, Patricia
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De Roos, Annecla ...
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Cozen, Wendy
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Zhi, Degui
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Akers, Nicholas ...
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Riby, Jacques
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Smith, Martyn T
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Lacher, Mortimer
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Villano, Danylo ...
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Maria, Ann
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Roman, Eve
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Kane, Eleanor
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Jackson, Rebecca ...
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North, Kari E
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Diver, W Ryan
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Turner, Jenny
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Armstrong, Bruce ...
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Benavente, Yolan ...
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Boffetta, Paolo
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Brennan, Paul
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Foretova, Lenka
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Maynadie, Marc
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Staines, Anthony
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McKay, James
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Brooks-Wilson, A ...
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Zheng, Tongzhang
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Holford, Theodor ...
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Chamosa, Saioa
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Kaaks, Rudolph
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Kelly, Rachel S
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Ohlsson, Bodil
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Travis, Ruth C
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Weiderpass, Elis ...
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Clavel, Jacqueli ...
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Giovannucci, Edw ...
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Kraft, Peter
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Virtamo, Jarmo
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Mazza, Patrizio
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Cocco, Pierluigi
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Ennas, Maria Gra ...
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Chiu, Brian C H
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Fraumeni, Joseph ...
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Nieters, Alexand ...
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Offit, Kenneth
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Wu, Xifeng
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Cerhan, James R
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Smedby, Karin E
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Chanock, Stephen ...
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Rothman, Nathani ...
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Karolinska Institutet
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