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  • Asnicar, FrancescoUniversity of Trento (author)

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-11
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:5409314a-6333-4b46-bd89-04c4958c9e95
  • https://lup.lub.lu.se/record/5409314a-6333-4b46-bd89-04c4958c9e95URI
  • https://doi.org/10.1038/s41591-020-01183-8DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.

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  • Berry, Sarah E.King's College London (author)
  • Valdes, Ana M.Nottingham Biomedical Research Centre (BRC),University of Nottingham (author)
  • Nguyen, Long H.Harvard University,Massachusetts General Hospital (author)
  • Piccinno, GianmarcoUniversity of Trento (author)
  • Drew, David A.Massachusetts General Hospital,Harvard University (author)
  • Leeming, EmilyKing's College London (author)
  • Gibson, RachelKing's College London (author)
  • Le Roy, CarolineKing's College London (author)
  • Khatib, Haya AlZoe Global Limited (author)
  • Francis, LucyZoe Global Limited (author)
  • Mazidi, MohsenKing's College London (author)
  • Mompeo, OlatzKing's College London (author)
  • Valles-Colomer, MireiaUniversity of Trento (author)
  • Tett, AdrianUniversity of Trento (author)
  • Beghini, FrancescoUniversity of Trento (author)
  • Dubois, LéonardUniversity of Trento (author)
  • Bazzani, DavideUniversity of Trento (author)
  • Thomas, Andrew MaltezUniversity of Trento (author)
  • Mirzayi, ChloeCity University of New York (author)
  • Khleborodova, AsyaCity University of New York (author)
  • Oh, SehyunCity University of New York (author)
  • Hine, RachelZoe Global Limited (author)
  • Bonnett, ChristopherZoe Global Limited (author)
  • Capdevila, JoanZoe Global Limited (author)
  • Danzanvilliers, SergeZoe Global Limited (author)
  • Giordano, FrancescaZoe Global Limited (author)
  • Geistlinger, LudwigCity University of New York (author)
  • Waldron, LeviCity University of New York (author)
  • Davies, RichardZoe Global Limited (author)
  • Hadjigeorgiou, GeorgeZoe Global Limited (author)
  • Wolf, JonathanZoe Global Limited (author)
  • Ordovás, José M.Tufts University,Autonomous University of Madrid (author)
  • Gardner, ChristopherStanford University (author)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University(Swepub:lu)med-plf (author)
  • Chan, Andrew T.Massachusetts General Hospital,Harvard University,Broad Institute (author)
  • Huttenhower, CurtisHarvard University,Broad Institute (author)
  • Spector, Tim D.King's College London (author)
  • Segata, NicolaEuropean Institute of Oncology,University of Trento (author)
  • University of TrentoKing's College London (creator_code:org_t)

Related titles

  • In:Nature Medicine: Springer Science and Business Media LLC27:2, s. 321-3321078-89561546-170X

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