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Purkinje cell vulne...
Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits
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- Özen, Ilknur (författare)
- Lund University,Lunds universitet,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,Laboratory for Experimental Brain Research,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups
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- Mai, Hongcheng (författare)
- Helmholtz Zentrum Munchen, Insititute Tissue Engn & Regenerat Med iTERM, Neuherberg, Germany.;Ludwig Maximilian Univ Munich LMU, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany.
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- De Maio, Alessandro (författare)
- Lund Univ, Dept Clin Sci, Lund Brain Injury Lab Neurosurg Res, Lund, Sweden.,Lund University
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- Ruscher, Karsten (författare)
- Lund University,Lunds universitet,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,Laboratory for Experimental Brain Research,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups
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- Michalettos, Georgios (författare)
- Lund University,Lunds universitet,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups
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- Clausen, Fredrik, Docent, 1973- (författare)
- Uppsala University,Uppsala universitet,Neurokirurgi
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- Gottschalk, Michael (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Faculty of Medicine,Lund University Research Groups
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- Ansar, Saema (författare)
- Lund University,Lunds universitet,Neurovaskulär forskning,Forskargrupper vid Lunds universitet,Applied Neurovascular Research,Lund University Research Groups
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- Arkan, Sertan (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Erturk, Ali (författare)
- Helmholtz Zentrum Munchen, Insititute Tissue Engn & Regenerat Med iTERM, Neuherberg, Germany.;Ludwig Maximilian Univ Munich LMU, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany.
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- Marklund, Niklas (författare)
- Lund University,Lunds universitet,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Forskargrupper vid Lunds universitet,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2022-09-05
- 2022
- Engelska.
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Ingår i: Acta neuropathologica communications. - : Springer Nature. - 2051-5960. ; 10
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Cerebellar dysfunction is commonly observed following traumatic brain injury (TBI). While direct impact to the cerebellum by TBI is rare, cerebellar pathology may be caused by indirect injury via cortico-cerebellar pathways. To address the hypothesis that degeneration of Purkinje cells (PCs), which constitute the sole output from the cerebellum, is linked to long-range axonal injury and demyelination, we used the central fluid percussion injury (cFPI) model of widespread traumatic axonal injury in mice. Compared to controls, TBI resulted in early PC loss accompanied by alterations in the size of pinceau synapses and levels of non-phosphorylated neurofilament in PCs. A combination of vDISCO tissue clearing technique and immunohistochemistry for vesicular glutamate transporter type 2 show that diffuse TBI decreased mossy and climbing fiber synapses on PCs. At 2 days post-injury, numerous axonal varicosities were found in the cerebellum supported by fractional anisotropy measurements using 9.4 T MRI. The disruption and demyelination of the cortico-cerebellar circuits was associated with poor performance of brain-injured mice in the beam-walk test. Despite a lack of direct input from the injury site to the cerebellum, these findings argue for novel long-range mechanisms causing Purkinje cell injury that likely contribute to cerebellar dysfunction after TBI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Traumatic brain injury (TBI)
- Demyelination
- Axonal injury
- Cerebellum
- Purkinje cell
- Central (midline) fluid percussion
- vDISCO
- Axonal injury
- Central (midline) fluid percussion
- Cerebellum
- Demyelination
- Purkinje cell
- Traumatic brain injury (TBI)
- vDISCO
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Özen, Ilknur
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Mai, Hongcheng
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De Maio, Alessan ...
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Ruscher, Karsten
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Michalettos, Geo ...
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Clausen, Fredrik ...
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visa fler...
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Gottschalk, Mich ...
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Ansar, Saema
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Arkan, Sertan
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Erturk, Ali
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Marklund, Niklas
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Acta neuropathol ...
- Av lärosätet
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Uppsala universitet
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Lunds universitet