Impact of generic substitution on levetiracetam serum concentration : A prospective study in an outpatient setting

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:lup.lub.lu.se:54f1433b-3dda-499c-bad9-3d16b80a1f6a" > Impact of generic s...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Reimers, ArneNorwegian University of Science and Technology (author)

Impact of generic substitution on levetiracetam serum concentration : A prospective study in an outpatient setting

Article/chapterEnglish2017

Publisher, publication year, extent ...

Elsevier BV,2017
8 s.

Numbers

LIBRIS-ID:oai:lup.lub.lu.se:54f1433b-3dda-499c-bad9-3d16b80a1f6a
https://lup.lub.lu.se/record/54f1433b-3dda-499c-bad9-3d16b80a1f6aURI
https://doi.org/10.1016/j.eplepsyres.2017.04.017DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:art swepub-publicationtype
Subject category:ref swepub-contenttype

Notes

BACKGROUND: Switching patients from a branded antiepileptic drug (AED) to a generic is often challenging. Several studies have shown that considerable proportions of patients report deteriorated seizure control or increased adverse effects, enforcing a switchback to the original drug. Since tolerability and seizure control usually correlate with AED serum concentrations, we examined the fluctuation of levetiracetam (LEV) serum concentrations in patients with epilepsy before and after generic substitution.METHODS: This was an 18-week, naturalistic, open, prospective, two-center study. After a baseline period of 10 weeks, 33 outpatients on stable treatment with branded LEV (Keppra(®)) either continued with this product or were switched overnight to a generic LEV preparation (1A Pharma) for an eight-week study period. Throughout the study, patients were monitored with bi-weekly LEV serum concentration measurements and seizure diaries.RESULTS: 16 out of 33 patients were switched to a generic LEV product. No switchbacks were seen. LEV dose, LEV serum concentrations, fluctuation index and concentration/dose-ratio (C/D-ratio) were not significantly different within-group (baseline vs. study period) or between-group. Large within-subject variability in serum concentrations was seen in both groups. None of the patients that were seizure-free before inclusion experienced seizures while on the generic LEV product.CONCLUSIONS: Our results show equal fluctuation of LEV serum concentrations with branded LEV and the generic LEV. Most importantly, within-subject variability was much larger than the small, non-significant differences between brands.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Journal Article

Added entries (persons, corporate bodies, meetings, titles ...)

Olsson, PatrikLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital(Swepub:lu)pa5432ol (author)
Nilsson, JohannaLund University (author)
Hoff, ElinLund University (author)
Reis, MargaretaSkåne University Hospital(Swepub:lu)klin-mre (author)
Strandberg, MariaSkåne University Hospital (author)
Lundgren, AndersHelsingborg Hospital(Swepub:lu)neur-alu (author)
Källén, KristinaLund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Helsingborg Hospital(Swepub:lu)neur-kka (author)
Norwegian University of Science and TechnologyKliniska Vetenskaper, Helsingborg (creator_code:org_t)

Related titles

In:Epilepsy Research: Elsevier BV134, s. 54-611872-68440920-1211

Internet link

Find in a library

Epilepsy Research (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Reimers, Arne; Olsson, Patrik; Nilsson, Johanna; Hoff, Elin; Reis, Margareta; Strandberg, Mari ...; show more...; Lundgren, Anders; Källén, Kristina; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Anesthesiology a ...

Articles in the publication: Epilepsy Researc ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se