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- Xu, D.Erasmus University Medical Center (author)
Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- Elsevier BV,2021
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- LIBRIS-ID:oai:lup.lub.lu.se:55441dc3-9aee-44f5-93a2-38ec1c2e5a93
- https://lup.lub.lu.se/record/55441dc3-9aee-44f5-93a2-38ec1c2e5a93URI
- https://doi.org/10.1016/j.joca.2021.07.007DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Objective: To explore the interplay between (changes in) medial meniscus volume, meniscus extrusion and radiographic knee osteoarthritis (OA) development over 30 months follow-up (FU). Methods: Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 middle-aged women with a body mass index ≥27 kg/m2, who were free of knee OA at baseline. Demographics were collected by questionnaires at baseline. All menisci at both baseline and FU were automatically segmented from MRI scans to obtain the meniscus volume and the change over time (delta volume). Baseline and FU meniscus body extrusion was quantitatively measured on mid-coronal proton density MR images. A structural equation model was created to assess the interplay between both medial meniscus volume and central extrusion at baseline, delta volume, delta extrusion, and incident radiographic knee OA at FU. Results: The structural equation modeling yielded a fair to good fit of the data. The direct effects of both medial meniscus volume and extrusion at baseline on incident OA were statistically significant (Estimate = 0.124, p = 0.029, and Estimate = 0.194, p < 0.001, respectively). Additional indirect effects on incident radiographic OA through delta meniscus volume or delta meniscus extrusion were not statistically significant. Conclusion: Baseline medial meniscus volume and extrusion were associated to incidence of radiographic knee OA at FU in middle-aged overweight and obese women, while their changes were not involved in these effects. To prevent knee OA, interventions might need to target the onset of meniscal pathologies rather than their progression.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
- Knee osteoarthritis
- Meniscus extrusion
- Meniscus volume
- MRI
Added entries (persons, corporate bodies, meetings, titles ...)
- van der Voet, J.Erasmus University Medical Center (author)
- Waarsing, J. H.Erasmus University Medical Center (author)
- Oei, E. H.Erasmus University Medical Center (author)
- Klein, S.Erasmus University Medical Center (author)
- Englund, M.Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ort-med (author)
- Zhang, F.Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-faz (author)
- Bierma-Zeinstra, S.Erasmus University Medical Center (author)
- Runhaar, J.Erasmus University Medical Center (author)
- Erasmus University Medical CenterOrtopedi, Lund (creator_code:org_t)
Related titles
- In:Osteoarthritis and Cartilage: Elsevier BV29:10, s. 1426-14311063-4584
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