Noninvasive characterization of atrioventricular conduction in patients with atrial fibrillation.

The atrioventricular (AV) node plays a fundamental role in patients with atrial fibrillation (AF), acting as a filter to the numerous irregular atrial impulses which bombard the node. A phenomenological approach to better understand AV nodal electrophysiology is to analyze the ventricular response with respect to irregularity. In different cohorts of AF patients, such analysis has been performed with the aim to evaluate the association between ventricular response characteristics and long-term clinical outcome and to determine whether irregularity is affected by rate-control drugs. Another approach to studying AV nodal characteristics is to employ a mathematical model which accounts for the refractory periods of the two AV nodal pathways. With atrial fibrillatory rate and RR intervals as input, the model has been considered for analyzing data during (i) rest and head-up tilt test, (ii) tecadenoson and esmolol, and (iii) rate-control drugs. The present paper provides an overview of our recent work on the characterization and assessment of AV nodal conduction using these two approaches.

Sandberg, FridaLund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Medicin och teknik (CI),Utbildningsprogram, LTH,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Biomedical Engineering (M.Sc.Eng.),Educational programmes, LTH,Faculty of Engineering, LTH(Swepub:lu)es-fni (författare)
Mainardi, Luca TPolytechnic University of Milan (författare)
Platonov, PyotrLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kard-ppl (författare)
Sörnmo, LeifLund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Medicin och teknik (CI),Utbildningsprogram, LTH,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Biomedical Engineering (M.Sc.Eng.),Educational programmes, LTH,Faculty of Engineering, LTH(Swepub:lu)tde-lso (författare)
Polytechnic University of MilanAvdelningen för Biomedicinsk teknik (creator_code:org_t)

Ingår i:Journal of Electrocardiology: Elsevier BV48:6, s. 938-9421532-84300022-0736

Av författaren/redakt...: Corino, Valentin ...; Sandberg, Frida; Mainardi, Luca T; Platonov, Pyotr; Sörnmo, Leif

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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