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TRIM28 repression o...
TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells
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Rowe, Helen M. (author)
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Kapopoulou, Adamandia (author)
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Corsinotti, Andrea (author)
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- Fasching, Liana (author)
- Lund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups
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Macfarlan, Todd S. (author)
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Tarabay, Yara (author)
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Viville, Stephane (author)
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- Jakobsson, Johan (author)
- Lund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups
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Pfaff, Samuel L. (author)
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Trono, Didier (author)
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(creator_code:org_t)
- 2012-12-10
- 2013
- English.
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In: Genome Research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 23:3, s. 452-461
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Abstract
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- TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these retroelements. In TRIM28-depleted ES cells, repressive chromatin marks at ERVs are replaced by histone modifications typical of active enhancers, stimulating transcription of nearby cellular genes, notably those harboring bivalent promoters. Correspondingly, ERV-derived sequences can repress or enhance expression from an adjacent promoter in transgenic embryos depending on their TRIM28 sensitivity in ES cells. TRIM28-mediated control of ERVs is therefore crucial not just to prevent retrotransposition, but more broadly to safeguard the transcriptional dynamics of early embryos.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Rowe, Helen M.
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Kapopoulou, Adam ...
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Corsinotti, Andr ...
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Fasching, Liana
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Macfarlan, Todd ...
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Tarabay, Yara
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show more...
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Viville, Stephan ...
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Jakobsson, Johan
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Pfaff, Samuel L.
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Trono, Didier
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Genome Research
- By the university
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Lund University