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Genome-wide analysi...
Genome-wide analysis yields new loci associating with aortic valve stenosis
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- Helgadottir, Anna (author)
- deCODE Genetics
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- Thorleifsson, Gudmar (author)
- deCODE Genetics
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- Gretarsdottir, Solveig (author)
- deCODE Genetics
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show more...
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- Stefansson, Olafur A. (author)
- deCODE Genetics
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- Tragante, Vinicius (author)
- deCODE Genetics
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- Thorolfsdottir, Rosa B. (author)
- deCODE Genetics
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- Jonsdottir, Ingileif (author)
- deCODE Genetics,University of Iceland
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- Bjornsson, Thorsteinn (author)
- deCODE Genetics
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- Steinthorsdottir, Valgerdur (author)
- deCODE Genetics
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- Verweij, Niek (author)
- University Medical Center Groningen,Broad Institute
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- Nielsen, Jonas B. (author)
- University of Michigan
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- Zhou, Wei (author)
- University of Michigan
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- Folkersen, Lasse (author)
- Karolinska University Hospital,Technical University of Denmark
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- Martinsson, Andreas (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Heydarpour, Mahyar (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Prakash, Siddharth (author)
- University of Texas
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- Oskarsson, Gylfi (author)
- National University Hospital of Iceland
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- Gudbjartsson, Tomas (author)
- National University Hospital of Iceland
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- Geirsson, Arnar (author)
- Yale University
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- Olafsson, Isleifur (author)
- National University Hospital of Iceland
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- Sigurdsson, Emil L. (author)
- University of Iceland
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Melander, Olle (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet,Karolinska University Hospital
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- Hamsten, Anders (author)
- Karolinska Institutet,Karolinska University Hospital
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- Fritsche, Lars (author)
- Norwegian University of Science and Technology
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- Lin, Maoxuan (author)
- University of Michigan
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- Yang, Bo (author)
- University of Michigan
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- Hornsby, Whitney (author)
- University of Michigan
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- Guo, Dongchuan (author)
- University of Texas
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- Brummett, Chad M. (author)
- University of Michigan
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- Abecasis, Gonçalo (author)
- University of Michigan
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- Mathis, Michael (author)
- University of Michigan
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- Milewicz, Dianna (author)
- Texas Heart Institute,University of Texas
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- Body, Simon C. (author)
- Brigham and Women's Hospital / Harvard Medical School
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- Eriksson, Per (author)
- Karolinska Institutet,Karolinska University Hospital
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- Willer, Cristen J. (author)
- University of Michigan
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- Hveem, Kristian (author)
- Norwegian University of Science and Technology
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- Newton-Cheh, Christopher (author)
- Broad Institute,Massachusetts General Hospital
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- Smith, J. Gustav (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Danielsen, Ragnar (author)
- National University Hospital of Iceland
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- Thorgeirsson, Gudmundur (author)
- National University Hospital of Iceland,deCODE Genetics,University of Iceland
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- Thorsteinsdottir, Unnur (author)
- deCODE Genetics,University of Iceland
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- Gudbjartsson, Daniel F. (author)
- deCODE Genetics,University of Iceland
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- Holm, Hilma (author)
- deCODE Genetics
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- Stefansson, Kari (author)
- University of Iceland,deCODE Genetics
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(creator_code:org_t)
- 2018-03-07
- 2018
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10-22) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10-13). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10-10) and aortic root diameter (P = 1.30 × 10-8), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10-3) and coronary artery disease (OR = 1.05, P = 9.3 × 10-5). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Helgadottir, Ann ...
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Thorleifsson, Gu ...
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Gretarsdottir, S ...
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Stefansson, Olaf ...
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Tragante, Vinici ...
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Thorolfsdottir, ...
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Jonsdottir, Ingi ...
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Bjornsson, Thors ...
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Steinthorsdottir ...
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Verweij, Niek
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Nielsen, Jonas B ...
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Zhou, Wei
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Folkersen, Lasse
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Martinsson, Andr ...
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Heydarpour, Mahy ...
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Prakash, Siddhar ...
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Oskarsson, Gylfi
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Gudbjartsson, To ...
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Geirsson, Arnar
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Olafsson, Isleif ...
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Sigurdsson, Emil ...
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Almgren, Peter
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Melander, Olle
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Franco-Cereceda, ...
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Hamsten, Anders
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Fritsche, Lars
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Lin, Maoxuan
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Yang, Bo
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Hornsby, Whitney
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Guo, Dongchuan
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Brummett, Chad M ...
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Abecasis, Gonçal ...
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Mathis, Michael
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Milewicz, Dianna
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Body, Simon C.
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Eriksson, Per
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Willer, Cristen ...
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Hveem, Kristian
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Newton-Cheh, Chr ...
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Smith, J. Gustav
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Danielsen, Ragna ...
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Thorgeirsson, Gu ...
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Thorsteinsdottir ...
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Gudbjartsson, Da ...
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Holm, Hilma
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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Karolinska Institutet