Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Rasmusson Allan G.) > Matrix Redox Physio...

Møller, Ian MaxAarhus University (författare)

Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications

Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

2020-01-06
Oxford University Press (OUP),2020
22 s.

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:56025bdc-d24f-4d9d-9f68-a72d0465ce8a
https://lup.lub.lu.se/record/56025bdc-d24f-4d9d-9f68-a72d0465ce8aURI
https://doi.org/10.1105/tpc.19.00535DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:for swepub-publicationtype
Ämneskategori:ref swepub-contenttype

Anmärkningar

Mitochondria function as hubs of plant metabolism. Oxidative phosphorylation produces ATP, but it is also a central high-capacity electron sink required by many metabolic pathways that must be flexibly coordinated and integrated. Here, we review the crucial roles of redox-associated posttranslational protein modifications (PTMs) in mitochondrial metabolic regulation. We discuss several major concepts. First, the major redox couples in the mitochondrial matrix (NAD, NADP, thioredoxin, glutathione, and ascorbate) are in kinetic steady state rather than thermodynamic equilibrium. Second, targeted proteomics have produced long lists of proteins potentially regulated by Cys oxidation/thioredoxin, Met-SO formation, phosphorylation, or Lys acetylation, but we currently only understand the functional importance of a few of these PTMs. Some site modifications may represent molecular noise caused by spurious reactions. Third, different PTMs on the same protein or on different proteins in the same metabolic pathway can interact to fine-tune metabolic regulation. Fourth, PTMs take part in the repair of stress-induced damage (e.g., by reducing Met and Cys oxidation products) as well as adjusting metabolic functions in response to environmental variation, such as changes in light irradiance or oxygen availability. Finally, PTMs form a multidimensional regulatory system that provides the speed and flexibility needed for mitochondrial coordination far beyond that provided by changes in nuclear gene expression alone.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

Igamberdiev, Abir U.Memorial University of Newfoundland (författare)
Bykova, Natalia V.Agriculture and Agri-Food Canada (AAFC) (författare)
Finkemeier, IrisUniversity of Münster (författare)
Rasmusson, Allan G.Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)fysb-ara (författare)
Schwarzländer, MarkusUniversity of Münster (författare)
Aarhus UniversityMemorial University of Newfoundland (creator_code:org_t)

Sammanhörande titlar

Ingår i:The Plant cell: Oxford University Press (OUP)32:3, s. 573-5941040-46511532-298X

Internetlänk

Hitta via bibliotek

The Plant cell (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Møller, Ian Max; Igamberdiev, Abi ...; Bykova, Natalia ...; Finkemeier, Iris; Rasmusson, Allan ...; Schwarzländer, M ...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biokemi och mole ...

Artiklar i publikationen: The Plant cell

Av lärosätet: Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se