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Short article : Influence of regulatory NLRC5 variants on colorectal cancer survival and 5-fluorouracil-based chemotherapy
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- Catalano, Calogerina (författare)
- German Cancer Research Centre
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- Da Silva Filho, Miguel I. (författare)
- German Cancer Research Centre
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- Jiraskova, Katerina (författare)
- Charles University in Prague,Academy of Sciences of the Czech Republic
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- Vymetalkova, Veronika (författare)
- Academy of Sciences of the Czech Republic,Charles University in Prague
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- Levy, Miroslav (författare)
- Charles University in Prague
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- Liska, Vaclav (författare)
- Charles University in Prague
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- Vycital, Ondrej (författare)
- Charles University in Prague
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- Naccarati, Alessio (författare)
- Academy of Sciences of the Czech Republic
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- Vodickova, Ludmila (författare)
- Academy of Sciences of the Czech Republic,Charles University in Prague
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- Hemminki, Kari (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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- Vodicka, Pavel (författare)
- Charles University in Prague,Academy of Sciences of the Czech Republic
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- Weber, Alexander N.R. (författare)
- University of Tübingen
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- Försti, Asta (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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(creator_code:org_t)
- 2018
- 2018
- Engelska 5 s.
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Ingår i: European Journal of Gastroenterology and Hepatology. - 0954-691X. ; 30:8, s. 838-842
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background NLRC5 is an interferon γ-inducible protein, which plays a role in immune surveillance with a potential influence on cancer survival. Objective We aimed to evaluate the effect of potential regulatory variants in NLRC5 on overall survival and survival after 5-fluorouracil (5-FU)-based therapy of colorectal cancer (CRC) patients. Patients and methods We carried out a case-only study in a Czech population of 589 cases; 232 received 5-FU-based therapy. Eleven variants within NLRC5 were selected using in-silico tools. Associations between polymorphisms and survival were assessed by Cox regression analysis adjusting for age at diagnosis, sex, and TNM stage. Survival curves were derived using the Kaplan-Meier method. Results Two variants showed a significant association with survival. All patients and metastasis-free patients at the time of diagnosis (pM0) who were homozygous carriers of the minor allele of rs27194 had a decreased overall survival (OS all and OS pM0) and event-free survival (EFS pM0) under a recessive model (OS all P=0.003, OS pM0 P=0.005, EFS pM0 P=0.01, respectively). OS was also decreased for all patients and for pM0 patients who carried at least one minor allele of rs289747 (OS all P=0.03 and OS pM0 P=0.003, respectively). Among CRC patients, who underwent a 5-FU-based adjuvant regimen, rs12445252 was associated with OS all, OS pM0 and EFS pM0, according to the dosage of the minor allele T (OS all P=0.0004, OS pM0 P=0.0001, EFS pM0 P=0.008, respectively). Conclusion Our results showed that polymorphisms in NLRC5 may be used as prognostic markers of survival of CRC patients, as well as for survival in response to 5-FU treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- 5-fluorouracil
- colorectal cancer
- NLRC5
- survival analysis
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Catalano, Caloge ...
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Da Silva Filho, ...
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Jiraskova, Kater ...
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Vymetalkova, Ver ...
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Levy, Miroslav
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Liska, Vaclav
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visa fler...
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Vycital, Ondrej
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Naccarati, Aless ...
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Vodickova, Ludmi ...
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Hemminki, Kari
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Vodicka, Pavel
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Weber, Alexander ...
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Försti, Asta
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